Kyoungjune Pak1, Gi Jeong Cheon, Keon Wook Kang, June-Key Chung, E Edmund Kim, Dong Soo Lee. 1. From the *Department of Nuclear Medicine, Seoul National University Hospital, Seoul; †Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan; ‡Cancer Research Institute, Seoul National University Hospital; and §Department of Molecular Medicine and Biopharmaceutical Science, WCU Graduate School of Concergence Science and Technology, Seoul National University, Seoul, Korea; and ∥University of California at Irvine, Irvine, CA.
Abstract
PURPOSE: We investigated whether SUV parameters, from PET, can provide prognostic information for patients with oropharyngeal or hypopharyngeal cancer. PATIENTS AND METHODS: Forty-eight patients with oropharyngeal or hypopharyngeal cancer who underwent PET before treatment were enrolled. A volume of interest was placed on PET images covering the entire tumor volume and metastatic lymph nodes, and the SUVmax, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. RESULTS: With the use of Kaplan-Meier analysis, age, SUVmean, MTV, and TLG predicted decreased disease-free survival (DFS). However, SUVmax was not associated with DFS. In multivariate analysis, the variables were included in 3 separate models. An SUVmean2.5 was an independent prognostic factor for DFS. Other SUV parameters, such as MTV and TLG, were associated with trends toward a decreasing DFS. CONCLUSIONS: SUVmean of PET was an independent prognostic factor for DFS in patients with oropharyngeal and hypopharyngeal cancer.
PURPOSE: We investigated whether SUV parameters, from PET, can provide prognostic information for patients with oropharyngeal or hypopharyngeal cancer. PATIENTS AND METHODS: Forty-eight patients with oropharyngeal or hypopharyngeal cancer who underwent PET before treatment were enrolled. A volume of interest was placed on PET images covering the entire tumor volume and metastatic lymph nodes, and the SUVmax, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. RESULTS: With the use of Kaplan-Meier analysis, age, SUVmean, MTV, and TLG predicted decreased disease-free survival (DFS). However, SUVmax was not associated with DFS. In multivariate analysis, the variables were included in 3 separate models. An SUVmean2.5 was an independent prognostic factor for DFS. Other SUV parameters, such as MTV and TLG, were associated with trends toward a decreasing DFS. CONCLUSIONS: SUVmean of PET was an independent prognostic factor for DFS in patients with oropharyngeal and hypopharyngeal cancer.
Authors: Peter Lin; Myo Min; Mark Lee; Lois Holloway; Dion Forstner; Victoria Bray; Allan Fowler Journal: Eur J Nucl Med Mol Imaging Date: 2016-12-21 Impact factor: 9.236
Authors: Jefferson Rijo-Cedeño; Jorge Mucientes; Ithzel María Villarreal; Ana Royuela; Patricia García Vicente; José Ramón García-Berrocal Journal: Eur Arch Otorhinolaryngol Date: 2022-05-02 Impact factor: 3.236