Literature DB >> 2542330

Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons.

Y H Hsiang1, L F Liu.   

Abstract

Like many intercalative antitumor drugs, the nonintercalative antitumor drug epipodophyllotoxin VM-26 (teniposide) induces topoisomerase II-linked DNA breaks as revealed by cell lysis with a strong protein denaturant such as sodium dodecyl sulfate or alkali. We show that the majority of topoisomerase II-linked DNA breaks reflect the formation of reversible topoisomerase II-DNA cleavable complexes in drug-treated cells by demonstrating the reversibility of this unusual type of DNA damage at elevated temperatures (e.g. 65 degrees C).

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Year:  1989        PMID： 2542330

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  30 in total

1.  An antitumor drug-induced topoisomerase cleavage complex blocks a bacteriophage T4 replication fork in vivo.

Authors:  G Hong; K N Kreuzer
Journal:  Mol Cell Biol       Date:  2000-01       Impact factor: 4.272

2.  Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisomerase complexes.

Authors:  George Hong; Kenneth N Kreuzer
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-18       Impact factor: 11.205

3.  Incomplete reversion of double stranded DNA cleavage mediated by Drosophila topoisomerase II: formation of single stranded DNA cleavage complex in the presence of an anti-tumor drug VM26.

Authors:  M P Lee; T Hsieh
Journal:  Nucleic Acids Res       Date:  1992-10-11       Impact factor: 16.971

4.  True reversal of Mu integration.

Authors:  T K Au; Shailja Pathania; Rasika M Harshey
Journal:  EMBO J       Date:  2004-07-29       Impact factor: 11.598

5.  DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.

Authors:  A Y Chen; C Yu; B Gatto; L F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

6.  Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.

Authors:  Y Kwok; Q Zeng; L H Hurley
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

7.  A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential.

Authors:  A H Corbett; P Guerry; P Pflieger; N Osheroff
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

8.  Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation.

Authors:  T A Shapiro
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

9.  Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin.

Authors:  N Fujii; Y Yamashita; Y Arima; M Nagashima; H Nakano
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

10.  (-)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIα inhibition and reactive oxygen species.

Authors:  Shuso Takeda; Momoko Noguchi; Kazumasa Matsuo; Yasuhiro Yamaguchi; Taichi Kudo; Hajime Nishimura; Yoshiko Okamoto; Toshiaki Amamoto; Mitsuru Shindo; Curtis J Omiecinski; Hironori Aramaki
Journal:  Toxicology       Date:  2013-01-08       Impact factor: 4.221
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