| Literature DB >> 25423177 |
Vitalij V Levin1, Alexey L Trifonov, Artem A Zemtsov, Marina I Struchkova, Dmitry E Arkhipov, Alexander D Dilman.
Abstract
A method for nucleophilic difluoromethylation of reactive Michael acceptors, aldehydes, and azomethines is described. The reaction is performed using the readily available and air-stable reagent difluoromethylene phosphabetaine. The process involves interaction of an electrophilic substrate with in situ generated difluorinated phosphonium ylide followed by hydrolysis of the carbon-phosphorus bond under mild conditions.Entities:
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Year: 2014 PMID： 25423177 DOI： 10.1021/ol503225s
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005