Literature DB >> 25422088

The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases.

D Ganea1, K M Hooper, W Kong.   

Abstract

Neuropeptides represent an important category of endogenous contributors to the establishment and maintenance of immune deviation in the immune-privileged organs such as the CNS and in the control of acute inflammation in the peripheral immune organs. Vasoactive intestinal peptide (VIP) is a major immunoregulatory neuropeptide widely distributed in the central and peripheral nervous system. In addition to neurones, VIP is synthesized by immune cells which also express VIP receptors. Here, we review the current information on VIP production and VIP-receptor-mediated effects in the immune system, the role of endogenous and exogenous VIP in inflammatory and autoimmune disorders and the present and future VIP therapeutic approaches.
© 2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  T-cell differentiation; autoimmune diseases; innate immunity; neuropeptides; tolerogenic dendritic cells; vasoactive intestinal peptide

Mesh：

Substances：

Year:  2014        PMID： 25422088      PMCID： PMC4484298          DOI： 10.1111/apha.12427

Source DB:  PubMed          Journal:  Acta Physiol (Oxf)        ISSN： 1748-1708            Impact factor:   6.311


  96 in total

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