| Literature DB >> 25421673 |
Abstract
Colorectal cancer (CRC) is one of most common malignancies and a leading cause of cancer related deaths worldwide. Epigenetic change is an important mechanism of colorectal carcinogenesis. Accumulation of epigenetic changes was found in colorectal cancer and other tumors. Aberrant changes in DNA methylation, histone modification, imprinting, and noncoding RNAs were frequently found in human colorectal cancer. Epigenetic changes may serve as a diagnostic, prognostic, and chemo-sensitive marker. It also becomes a cancer preventive or therapeutic target in some circumstances.Entities:
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Year: 2015 PMID: 25421673 DOI: 10.1007/978-1-4939-1804-1_22
Source DB: PubMed Journal: Methods Mol Biol ISSN: 1064-3745