Eva Bengtsson Moström1, Eveliina Lammentausta2,3, Thröstur Finnbogason4, Lars Weidenhielm5, Per-Mats Janarv1, Carl Johan Tiderius6. 1. Department of Womens and Childrens Health, Karolinska Institutet, Stockholm, Sweden. 2. Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. 3. Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. 4. Department of Paediatric Radiology, Karolinska University Hospital, Stockholm, Sweden. 5. Stockholm Sports Trauma Research Center, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. 6. Department of Orthopaedics, Skane University Hospital, Lund University, Lund, Sweden.
Abstract
PURPOSE: To examine the cartilage quality in young adults with recurrent patellar dislocation in childhood using different magnetic resonance imaging parameters. METHODS: Sixteen young adults with unilateral recurrent patellar dislocation were investigated ≥5 y (mean, 8.5 y) after the first dislocation. Pre- and postcontrast T1 and precontrast T2 relaxation times were analyzed in four superficial and four deep patellar cartilage regions of both knees. Two hours after intravenous injection of 0.2 mM/kg Gd-DTPA(2-), postcontrast T1 [T1(Gd)] and ΔR1 [1/T1 (precontrast) - 1/T1 (postcontrast)] were analyzed in the regions. Muscle performance and patient-reported outcome were evaluated. RESULTS: When comparing the injured side with the noninjured side, differences were seen in the superficial half but not the deep half of the cartilage. T1(Gd) was shorter in the central part, whereas T2 was shorter in the periphery of the patellar cartilage (P < 0.05). ΔR1 demonstrated similar differences between healthy and diseased cartilage as T1(Gd) alone. The knee function was not correlated to the degenerative changes. CONCLUSION: The short T1(Gd) centrally indicates degenerative cartilage changes consistent with loss of glycosaminoglycans. Precontrast and ΔR1 calculations may be excluded in clinical dGEMRIC, which simplifies the procedure. A decrease in T2 may be a very early sign of joint pathology but warrants further investigation.
PURPOSE: To examine the cartilage quality in young adults with recurrent patellar dislocation in childhood using different magnetic resonance imaging parameters. METHODS: Sixteen young adults with unilateral recurrent patellar dislocation were investigated ≥5 y (mean, 8.5 y) after the first dislocation. Pre- and postcontrast T1 and precontrast T2 relaxation times were analyzed in four superficial and four deep patellar cartilage regions of both knees. Two hours after intravenous injection of 0.2 mM/kg Gd-DTPA(2-), postcontrast T1 [T1(Gd)] and ΔR1 [1/T1 (precontrast) - 1/T1 (postcontrast)] were analyzed in the regions. Muscle performance and patient-reported outcome were evaluated. RESULTS: When comparing the injured side with the noninjured side, differences were seen in the superficial half but not the deep half of the cartilage. T1(Gd) was shorter in the central part, whereas T2 was shorter in the periphery of the patellar cartilage (P < 0.05). ΔR1 demonstrated similar differences between healthy and diseased cartilage as T1(Gd) alone. The knee function was not correlated to the degenerative changes. CONCLUSION: The short T1(Gd) centrally indicates degenerative cartilage changes consistent with loss of glycosaminoglycans. Precontrast and ΔR1 calculations may be excluded in clinical dGEMRIC, which simplifies the procedure. A decrease in T2 may be a very early sign of joint pathology but warrants further investigation.
Authors: John J Elias; Mei Li; Mingrui Yang; Richard Lartey; John P Murray; Lutul D Farrow; Carl S Winalski; Xiaojuan Li Journal: Cartilage Date: 2022 Apr-Jun Impact factor: 3.117
Authors: Joost Verschueren; Stephan J Van Langeveld; Jason L Dragoo; Sita M A Bierma-Zeinstra; Max Reijman; Garry E Gold; Edwin H G Oei Journal: Acta Orthop Date: 2021-02-04 Impact factor: 3.717
Authors: Eva Bengtsson Moström; Eveliina Lammentausta; Thröstur Finnbogason; Lars Weidenhielm; Per-Mats Janarv; Carl Johan Tiderius Journal: Acta Radiol Open Date: 2017-10-27
Authors: Yun-Sic Bang; Junbeom Park; Jihee Kim; Young-Soon Choi; Young Su Lim; Hyung Rae Cho; Young Uk Kim Journal: Clin Interv Aging Date: 2019-06-05 Impact factor: 4.458
Authors: Marc Sebastian Huppertz; Justus Schock; Karl Ludger Radke; Daniel Benjamin Abrar; Manuel Post; Christiane Kuhl; Daniel Truhn; Sven Nebelung Journal: Life (Basel) Date: 2021-03-05