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Literature DB >> 25420701

The synthesis of head-to-tail cyclic sulfono-γ-AApeptides.

Haifan Wu¹, Fengyu She, Wenyang Gao, Austin Prince, Yaqiong Li, Lulu Wei, Allison Mercer, Lukasz Wojtas, Shengqian Ma, Jianfeng Cai.

Abstract

We report an efficient method for the preparation of unprecedented head-to-tail cyclic sulfono-γ-AApeptides. Following this method, a number of cyclic sequences bearing two to five subunits were efficiently synthesized. In addition, the X-ray crystal structure study of a three-membered cyclic sulfono-γ-AApeptide revealed a type II β-turn-like character.

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Year: 2015 PMID： 25420701 DOI： 10.1039/c4ob02232g

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

10 in total

1. Antibacterial activity of lipo-α/sulfono-γ-AA hybrid peptides.

Authors: Lulu Wei; Minghui Wang; Ruixuan Gao; Rojin Fatirkhorani; Jianfeng Cai
Journal: Eur J Med Chem Date: 2019-11-19 Impact factor: 6.514

2. γ-AApeptides: Design, Structure, and Applications.

Authors: Yan Shi; Peng Teng; Peng Sang; Fengyu She; Lulu Wei; Jianfeng Cai
Journal: Acc Chem Res Date: 2016-02-22 Impact factor: 22.384

3. Inhibition of β-catenin/B cell lymphoma 9 protein-protein interaction using α-helix-mimicking sulfono-γ-AApeptide inhibitors.

Authors: Peng Sang; Min Zhang; Yan Shi; Chunpu Li; Sami Abdulkadir; Qi Li; Haitao Ji; Jianfeng Cai
Journal: Proc Natl Acad Sci U S A Date: 2019-05-14 Impact factor: 11.205

The synthesis of head-to-tail cyclic sulfono-γ-AApeptides.

1. Antibacterial activity of lipo-α/sulfono-γ-AA hybrid peptides.

2. γ-AApeptides: Design, Structure, and Applications.

3. Inhibition of β-catenin/B cell lymphoma 9 protein-protein interaction using α-helix-mimicking sulfono-γ-AApeptide inhibitors.

4. Small Antimicrobial Agents Based on Acylated Reduced Amide Scaffold.

Review 5. γ-AApeptides as a New Strategy for Therapeutic Development.

6. γ-AApeptides as a New Class of Peptidomimetics.

7. Membrane-Active Hydantoin Derivatives as Antibiotic Agents.

8. Sulfono-γ-AApeptides as Helical Mimetics: Crystal Structures and Applications.

9. Dimeric lipo-α/sulfono-γ-AA hybrid peptides as broad-spectrum antibiotic agents.

10. α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions.