Ashraf Yousef1, Ildar Akhtyamov2, Faina Shakirova3, Lyaili Zubairova4, Elmira Gatina5, Capital Ie Cyrilliclchin Aliev5. 1. Department of Orthopedic Surgery, New Mowasat Hospital Salmiya, Kuwait. 2. Department of Traumatology, Orthopedics and Extreme Medicine, Kazan State Medical University Kazan, Russia ; Republic Clinical Hospital Kazan, Russia. 3. Department of Veterinary Surgery, Kazan State Academy of Veterinary Medicine Kazan, Russia. 4. Department of Pathophysiology, Kazan State Medical University Kazan, Russia. 5. Department of Traumatology, Orthopedics and Extreme Medicine, Kazan State Medical University Kazan, Russia.
Abstract
PURPOSE: An experimental study comparing the dynamics of several biochemical markers before and after osteosynthesis, utilizing implants coated with titanium and hafnium nitrides and non-coated implants on rabbits' bones. MATERIALS AND METHODS: The Study has been conducted on 30 rabbits of both sexes, at the age of 6-7 months, weighing 2526.5±74.4 gm. Animals underwent open osteotomy of the tibia in the middle third of the diaphysis followed by the intramedullary nailing. The level of alkaline phosphatase, calcium, phosphorus, total protein, glucose, ALT and AST were monitored for 60 days. RESULTS: the use of implants coated with titanium and hafnium nitrides, which have high strength, thermal and chemical stability, was not accompanied by the development of additional negative reactive changes compared to non-coated implants. CONCLUSION: Nanotechnology used in manufacturing bioinert coatings for implants for osteosynthesis, has made the post-operative period less complicated as reflected by less expressed changing in the markers of bone metabolism and hepatotoxicity.
PURPOSE: An experimental study comparing the dynamics of several biochemical markers before and after osteosynthesis, utilizing implants coated with titanium and hafnium nitrides and non-coated implants on rabbits' bones. MATERIALS AND METHODS: The Study has been conducted on 30 rabbits of both sexes, at the age of 6-7 months, weighing 2526.5±74.4 gm. Animals underwent open osteotomy of the tibia in the middle third of the diaphysis followed by the intramedullary nailing. The level of alkaline phosphatase, calcium, phosphorus, total protein, glucose, ALT and AST were monitored for 60 days. RESULTS: the use of implants coated with titanium and hafnium nitrides, which have high strength, thermal and chemical stability, was not accompanied by the development of additional negative reactive changes compared to non-coated implants. CONCLUSION: Nanotechnology used in manufacturing bioinert coatings for implants for osteosynthesis, has made the post-operative period less complicated as reflected by less expressed changing in the markers of bone metabolism and hepatotoxicity.
Entities:
Keywords:
Implants; bioinert coating; osteosynthesis; titanium and hafnium nitrides
Authors: Kristina Akesson; Sanna-Maria Käkönen; Per Olof Josefsson; Magnus K Karlsson; Karl J Obrant; Kim Pettersson Journal: J Bone Miner Metab Date: 2005 Impact factor: 2.626