Literature DB >> 25418743

Predicting protein networks in cancer.

Andrea Califano1.   

Abstract

Characterization of the mutational landscape of tumors is important to understanding disease etiology but does not provide mechanistic insight into the functional role of specific mutations. A new study introduces a statistical mechanical framework that draws on biophysical data from SH2 domain-phosphoprotein interactions to predict the functional effects of mutations in cancer.

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Year:  2014        PMID： 25418743     DOI： 10.1038/ng.3156

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  6 in total

1.  Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.

Authors:  Bin Zhang; Chris Gaiteri; Liviu-Gabriel Bodea; Zhi Wang; Joshua McElwee; Alexei A Podtelezhnikov; Chunsheng Zhang; Tao Xie; Linh Tran; Radu Dobrin; Eugene Fluder; Bruce Clurman; Stacey Melquist; Manikandan Narayanan; Christine Suver; Hardik Shah; Milind Mahajan; Tammy Gillis; Jayalakshmi Mysore; Marcy E MacDonald; John R Lamb; David A Bennett; Cliona Molony; David J Stone; Vilmundur Gudnason; Amanda J Myers; Eric E Schadt; Harald Neumann; Jun Zhu; Valur Emilsson
Journal:  Cell       Date:  2013-04-25       Impact factor: 41.582

2.  Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.

Authors:  William A Freed-Pastor; Hideaki Mizuno; Xi Zhao; Anita Langerød; Sung-Hwan Moon; Ruth Rodriguez-Barrueco; Anthony Barsotti; Agustin Chicas; Wencheng Li; Alla Polotskaia; Mina J Bissell; Timothy F Osborne; Bin Tian; Scott W Lowe; Jose M Silva; Anne-Lise Børresen-Dale; Arnold J Levine; Jill Bargonetti; Carol Prives
Journal:  Cell       Date:  2012-01-20       Impact factor: 41.582

3.  Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks.

Authors:  James C Chen; Mariano J Alvarez; Flaminia Talos; Harshil Dhruv; Gabrielle E Rieckhof; Archana Iyer; Kristin L Diefes; Kenneth Aldape; Michael Berens; Michael M Shen; Andrea Califano
Journal:  Cell       Date:  2014-10-09       Impact factor: 41.582

4.  Mutations in the p53 gene occur in diverse human tumour types.

Authors:  J M Nigro; S J Baker; A C Preisinger; J M Jessup; R Hostetter; K Cleary; S H Bigner; N Davidson; S Baylin; P Devilee
Journal:  Nature       Date:  1989-12-07       Impact factor: 49.962

5.  A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.

Authors:  Mohammed AlQuraishi; Grigoriy Koytiger; Anne Jenney; Gavin MacBeath; Peter K Sorger
Journal:  Nat Genet       Date:  2014-11-02       Impact factor: 38.330

6.  Edgetic perturbation models of human inherited disorders.

Authors:  Quan Zhong; Nicolas Simonis; Qian-Ru Li; Benoit Charloteaux; Fabien Heuze; Niels Klitgord; Stanley Tam; Haiyuan Yu; Kavitha Venkatesan; Danny Mou; Venus Swearingen; Muhammed A Yildirim; Han Yan; Amélie Dricot; David Szeto; Chenwei Lin; Tong Hao; Changyu Fan; Stuart Milstein; Denis Dupuy; Robert Brasseur; David E Hill; Michael E Cusick; Marc Vidal
Journal:  Mol Syst Biol       Date:  2009-11-03       Impact factor: 11.429
  6 in total
  1 in total

1.  Understanding cancer complexome using networks, spectral graph theory and multilayer framework.

Authors:  Aparna Rai; Priodyuti Pradhan; Jyothi Nagraj; K Lohitesh; Rajdeep Chowdhury; Sarika Jalan
Journal:  Sci Rep       Date:  2017-02-03       Impact factor: 4.379
  1 in total

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