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Literature DB >> 25418741

Superparamagnetic iron oxide nanoparticle micelles stabilized by recombinant oleosin for targeted magnetic resonance imaging.

Kevin B Vargo¹, Ajlan Al Zaki, Robert Warden-Rothman, Andrew Tsourkas, Daniel A Hammer.

Abstract

Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle-loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody-oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets.

Entities: CellLine Chemical Disease Gene Species

Keywords: MRI contrast; contrast agents; iron oxide; oleosin; recombinant surfactants; targeting

Mesh：

Substances：

Year: 2014 PMID： 25418741 PMCID： PMC4746475 DOI： 10.1002/smll.201402017

Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281

17 in total

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Journal: Anal Biochem Date: 2000-12-15 Impact factor: 3.365

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Authors: Kevin B Vargo; Ranganath Parthasarathy; Daniel A Hammer
Journal: Proc Natl Acad Sci U S A Date: 2012-07-02 Impact factor: 11.205

3. Elevating bioavailability of curcumin via encapsulation with a novel formulation of artificial oil bodies.

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Journal: Magn Reson Med Date: 2005-02 Impact factor: 4.668

5. Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.

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6. Elevation of oil body integrity and emulsion stability by polyoleosins, multiple oleosin units joined in tandem head-to-tail fusions.

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Journal: Plant Biotechnol J Date: 2010-10 Impact factor: 9.803

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8. Tumor imaging using a picomolar affinity HER2 binding affibody molecule.

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Journal: Cancer Res Date: 2006-04-15 Impact factor: 12.701

9. Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency.

Authors: Lars Matuszewski; Thorsten Persigehl; Alexander Wall; Wolfram Schwindt; Bernd Tombach; Manfred Fobker; Christopher Poremba; Wolfgang Ebert; Walter Heindel; Christoph Bremer
Journal: Radiology Date: 2005-03-04 Impact factor: 11.105

10. Development of a mucin4-targeting SPIO contrast agent for effective detection of pancreatic tumor cells in vitro and in vivo.

Authors: Shou-Cheng Wu; Yu-Jen Chen; Yi-Jan Lin; Tung-Ho Wu; Yun-Ming Wang
Journal: J Med Chem Date: 2013-11-07 Impact factor: 7.446

9 in total

Review 1. Plant Lipid Droplets and Their Associated Proteins: Potential for Rapid Advances.

Authors: Anthony H C Huang
Journal: Plant Physiol Date: 2017-12-21 Impact factor: 8.340

Review 2. Bioimaging guided pharmaceutical evaluations of nanomedicines for clinical translations.

Authors: Ruslan G Tuguntaev; Abid Hussain; Chenxing Fu; Haoting Chen; Ying Tao; Yan Huang; Lu Liu; Xing-Jie Liang; Weisheng Guo
Journal: J Nanobiotechnology Date: 2022-05-19 Impact factor: 9.429

3. Site-Specific Labeling of Cyanine and Porphyrin Dye-Stabilized Nanoemulsions with Affibodies for Cellular Targeting.

Authors: Ahmad Amirshaghaghi; Burcin Altun; Kido Nwe; Lesan Yan; Joel M Stein; Zhiliang Cheng; Andrew Tsourkas
Journal: J Am Chem Soc Date: 2018-10-15 Impact factor: 15.419

4. Bioreducible Hydrophobin-Stabilized Supraparticles for Selective Intracellular Release.

Authors: Daniele Maiolo; Claudia Pigliacelli; Paola Sánchez Moreno; Martina Bruna Violatto; Laura Talamini; Ilaria Tirotta; Rosanna Piccirillo; Massimo Zucchetti; Lavinia Morosi; Roberta Frapolli; Gabriele Candiani; Paolo Bigini; Pierangelo Metrangolo; Francesca Baldelli Bombelli
Journal: ACS Nano Date: 2017-08-17 Impact factor: 15.881

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Authors: Zhenghuan Zhao; Muyao Li; Jie Zeng; Linlin Huo; Kun Liu; Ruixue Wei; Kaiyuan Ni; Jinhao Gao
Journal: Bioact Mater Date: 2021-10-19

6. Artificial Scaffold Polypeptides As an Efficient Tool for the Targeted Delivery of Nanostructures In Vitro and In Vivo.

Authors: V O Shipunova; S M Deyev
Journal: Acta Naturae Date: 2022 Jan-Mar Impact factor: 2.204