| Literature DB >> 25418524 |
Huizhen Liu1, Genevieve P S Lau1, Paul J Dyson1.
Abstract
Succinimide derivatives are useful building blocks for the synthesis of natural products and drugs. We describe an efficient route to succinimide derivatives comprising Pd(xantphos)Cl2-catalyzed aminocarbonylation of alkynes with aromatic or aliphatic amines in the presence of p-TsOH. The utility of this route is demonstrated with the synthesis of a large number of succinimide compounds including an important photochromic molecule.Entities:
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Year: 2014 PMID： 25418524 DOI： 10.1021/jo502412v
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354