| Literature DB >> 25418133 |
Oscar M Bautista-Aguilera1, Abdelouahid Samadi, Mourad Chioua, Katarina Nikolic, Slavica Filipic, Danica Agbaba, Elena Soriano, Lucía de Andrés, María Isabel Rodríguez-Franco, Stefano Alcaro, Rona R Ramsay, Francesco Ortuso, Matilde Yañez, José Marco-Contelles.
Abstract
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.Mesh：
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Year: 2014 PMID： 25418133 DOI： 10.1021/jm501501a
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446