| Literature DB >> 25417920 |
Delbert G Miles1, Karen C Rogers1.
Abstract
Pasteur described an organism causing fowl cholera in 1880. In 134 years we have progressed from crude vaccines for Pasteurella, to some refined vaccines, to a name change (Mannheimia), to autogenous vaccines (back to crude). In the last 25-30 years, we have attempted to mitigate the problem of bovine respiratory disease with antimicrobials and subsequently have a high incidence of multi-drug resistance. All of these attempts have resulted in little if any improvement in morbidity/mortality. Is it time to focus on the animal's response or lack of response to infectious pressure? Instead of focusing on the 10-50% morbid cattle should we focus on the 50-90% that are not compromised and determine why they stay healthy under the same environmental conditions?Entities:
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Year: 2014 PMID: 25417920 DOI: 10.1017/S1466252314000309
Source DB: PubMed Journal: Anim Health Res Rev ISSN: 1466-2523 Impact factor: 2.615