Pathology of brain and eye in the acquired immune deficiency syndrome (AIDS). A comparison of lesions in a consecutive autopsy material.

During the years 1984-1987, a consecutive Danish autopsy material of 43 AIDS cases was analysed in order to investigate a possible coincidence of pathological changes in brain and eye. In the brain, nodular gliosis/encephalitis was most frequent, followed by cytomegalovirus infection, which occurred twice as frequently as toxoplasmic infection and four times as frequently as fungal infection. In the eye, cytomegalovirus infection was most frequent and the only opportunistic infection, followed by retinal gliosis and cytoid body lesion. Malignant lymphoma was present in the brain in three patients, and in the choroid in two of these. In 11 patients, no changes of the brain were found. In eight of these the eye was also without pathological findings, while three had minor changes. In 22 patients the eye was normal, but in only eight of these was the brain without changes. Eight had nodular gliosis, and four a specific infection, while multifocal leucoencephalopathy and unspecified abscess each occurred in one patient. Comparison of the three opportunistic infections--CMV, toxoplasmosis and mycosis--in the three-year period showed an overall decreasing frequency, attributed to better medical care. It is concluded that concomitance of identical pathological lesions in brain and eye is less frequent than was expected.