| Literature DB >> 25417116 |
Abstract
To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.Mesh：
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Year: 2014 PMID： 25417116 DOI： 10.1016/j.cell.2014.10.012
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582