Daniel Pérez-Prieto1, Raúl Torres-Claramunt2, Pablo E Gelber3,4, Tamer M A Shehata5, Xavier Pelfort2,3, Joan Carles Monllau2,3. 1. Department of Orthopaedic Surgery and Traumatology, Consorci Parc de Salut Mar, Universitat Autònoma de Barcelona, Passeig Marítim, 25, Barcelona, Spain. dperezprieto@hospitaldelmar.cat. 2. Department of Orthopaedic Surgery and Traumatology, Consorci Parc de Salut Mar, Universitat Autònoma de Barcelona, Passeig Marítim, 25, Barcelona, Spain. 3. ICATME - Hospital Universitari Quirón-Dexeus, Universitat Autònoma de Barcelona, Barcelona, Spain. 4. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. 5. Mohamed Dossary Hospital, Al Khobar, Saudi Arabia.
Abstract
PURPOSE: To determine whether the bathing of an anterior cruciate ligament (ACL) autograft in vancomycin reduces the rate of infection following an ACL reconstruction. METHODS: Retrospective analysis of all ACL reconstructions over an 8-year period in two University Hospitals. In the initial 4-year period, all patients were operated on under classical antibiotic intravenous prophylaxis (group 1). Over the last 4-year period, this prophylaxis was supplemented with presoaking of the autograft (group 2). Presoaking was performed with sterile gauze previously saturated with a vancomycin solution (5 mg/ml). RESULTS: There were 810 and 734 patients in group 1 and 2, respectively. Fifteen cases of knee joint infections were identified in the series (0.97 %). All of these infections occurred in group 1, representing a rate of infection of 1.85 % in comparison with 0 % in group 2 (p < 0.001). CONCLUSIONS: Autograft presoaking with vancomycin in combination with classical intravenous antibiotic prophylaxis reduced the rate of knee joint infection following an ACLR in comparison with antibiotic prophylaxis alone. This technique could be of relevance in daily clinical practice to prevent infection after ACLR. LEVEL OF EVIDENCE: Case control study, retrospective comparative study, Level III.
PURPOSE: To determine whether the bathing of an anterior cruciate ligament (ACL) autograft in vancomycin reduces the rate of infection following an ACL reconstruction. METHODS: Retrospective analysis of all ACL reconstructions over an 8-year period in two University Hospitals. In the initial 4-year period, all patients were operated on under classical antibiotic intravenous prophylaxis (group 1). Over the last 4-year period, this prophylaxis was supplemented with presoaking of the autograft (group 2). Presoaking was performed with sterile gauze previously saturated with a vancomycin solution (5 mg/ml). RESULTS: There were 810 and 734 patients in group 1 and 2, respectively. Fifteen cases of knee joint infections were identified in the series (0.97 %). All of these infections occurred in group 1, representing a rate of infection of 1.85 % in comparison with 0 % in group 2 (p < 0.001). CONCLUSIONS: Autograft presoaking with vancomycin in combination with classical intravenous antibiotic prophylaxis reduced the rate of knee joint infection following an ACLR in comparison with antibiotic prophylaxis alone. This technique could be of relevance in daily clinical practice to prevent infection after ACLR. LEVEL OF EVIDENCE: Case control study, retrospective comparative study, Level III.
Authors: R Torres-Claramunt; X Pelfort; J Erquicia; S Gil-González; P E Gelber; L Puig; J C Monllau Journal: Knee Surg Sports Traumatol Arthrosc Date: 2012-10-27 Impact factor: 4.342
Authors: Joseph U Barker; Mark C Drakos; Travis G Maak; Russell F Warren; Riley J Williams; Answorth A Allen Journal: Am J Sports Med Date: 2009-11-13 Impact factor: 6.202
Authors: Daniel Pérez-Prieto; María E Portillo; Raúl Torres-Claramunt; Xavier Pelfort; Pedro Hinarejos; Joan C Monllau Journal: Knee Surg Sports Traumatol Arthrosc Date: 2017-10-07 Impact factor: 4.342
Authors: Tanner N Womble; John D King; Dustin H Hamilton; Max A Shrout; Cale A Jacobs; Stephen T Duncan Journal: J Arthroplasty Date: 2019-01-31 Impact factor: 4.757
Authors: Raúl Torres-Claramunt; Pablo Gelber; Xavier Pelfort; Pedro Hinarejos; Joan Leal-Blanquet; Daniel Pérez-Prieto; Joan C Monllau Journal: Int Orthop Date: 2015-08-04 Impact factor: 3.075