Literature DB >> 25416472

An integrated biotechnology platform for developing sustainable chemical processes.

Nelson R Barton1, Anthony P Burgard, Mark J Burk, Jason S Crater, Robin E Osterhout, Priti Pharkya, Brian A Steer, Jun Sun, John D Trawick, Stephen J Van Dien, Tae Hoon Yang, Harry Yim.   

Abstract

Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process.

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Year:  2014        PMID： 25416472     DOI： 10.1007/s10295-014-1541-1

Source DB:  PubMed          Journal:  J Ind Microbiol Biotechnol        ISSN： 1367-5435            Impact factor:   3.346


  24 in total

Review 1.  Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions.

Authors:  Paola Picotti; Ruedi Aebersold
Journal:  Nat Methods       Date:  2012-05-30       Impact factor: 28.547

2.  Respirometric 13C flux analysis--Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum.

Authors:  Tae Hoon Yang; Christoph Wittmann; Elmar Heinzle
Journal:  Metab Eng       Date:  2006-04-28       Impact factor: 9.783

Review 3.  The acetate switch.

Authors:  Alan J Wolfe
Journal:  Microbiol Mol Biol Rev       Date:  2005-03       Impact factor: 11.056

4.  Protein labeling by iTRAQ: a new tool for quantitative mass spectrometry in proteome research.

Authors:  Sebastian Wiese; Kai A Reidegeld; Helmut E Meyer; Bettina Warscheid
Journal:  Proteomics       Date:  2007-02       Impact factor: 3.984

5.  13C metabolic flux analysis for larger scale cultivation using gas chromatography-combustion-isotope ratio mass spectrometry.

Authors:  Yongbo Yuan; Tae Hoon Yang; Elmar Heinzle
Journal:  Metab Eng       Date:  2010-02-10       Impact factor: 9.783

Review 6.  From the first drop to the first truckload: commercialization of microbial processes for renewable chemicals.

Authors:  Stephen Van Dien
Journal:  Curr Opin Biotechnol       Date:  2013-03-25       Impact factor: 9.740

7.  j5 DNA assembly design automation software.

Authors:  Nathan J Hillson; Rafael D Rosengarten; Jay D Keasling
Journal:  ACS Synth Biol       Date:  2011-12-20       Impact factor: 5.110

8.  arcA (dye), a global regulatory gene in Escherichia coli mediating repression of enzymes in aerobic pathways.

Authors:  S Iuchi; E C Lin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

9.  The assimilation of gamma-butyrolactone in Agrobacterium tumefaciens C58 interferes with the accumulation of the N-acyl-homoserine lactone signal.

Authors:  Aurélien Carlier; Romain Chevrot; Yves Dessaux; Denis Faure
Journal:  Mol Plant Microbe Interact       Date:  2004-09       Impact factor: 4.171

10.  Dihydrolipoamide dehydrogenase mutation alters the NADH sensitivity of pyruvate dehydrogenase complex of Escherichia coli K-12.

Authors:  Youngnyun Kim; L O Ingram; K T Shanmugam
Journal:  J Bacteriol       Date:  2008-03-28       Impact factor: 3.490
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  8 in total

1.  Editorial.

Authors:  Jens Nielsen; Ramon Gonzalez
Journal:  J Ind Microbiol Biotechnol       Date:  2015-03       Impact factor: 3.346

Review 2.  Engineered biosynthesis of biodegradable polymers.

Authors:  Pooja Jambunathan; Kechun Zhang
Journal:  J Ind Microbiol Biotechnol       Date:  2016-06-03       Impact factor: 3.346

Review 3.  Production of C2-C4 diols from renewable bioresources: new metabolic pathways and metabolic engineering strategies.

Authors:  Ye Zhang; Dehua Liu; Zhen Chen
Journal:  Biotechnol Biofuels       Date:  2017-12-13       Impact factor: 6.040

4.  Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase.

Authors:  Ricardo Axayacatl Gonzalez-Garcia; Tim McCubbin; Annalena Wille; Manuel Plan; Lars Keld Nielsen; Esteban Marcellin
Journal:  Microb Cell Fact       Date:  2017-07-17       Impact factor: 5.328

5.  LCA of 1,4-Butanediol Produced via Direct Fermentation of Sugars from Wheat Straw Feedstock within a Territorial Biorefinery.

Authors:  Annachiara Forte; Amalia Zucaro; Riccardo Basosi; Angelo Fierro
Journal:  Materials (Basel)       Date:  2016-07-12       Impact factor: 3.623

Review 6.  Gas fermentation: cellular engineering possibilities and scale up.

Authors:  Björn D Heijstra; Ching Leang; Alex Juminaga
Journal:  Microb Cell Fact       Date:  2017-04-12       Impact factor: 5.328

Review 7.  A Review of the Biotechnological Production of Methacrylic Acid.

Authors:  Juliana Lebeau; John P Efromson; Michael D Lynch
Journal:  Front Bioeng Biotechnol       Date:  2020-03-20

8.  Exploring functionality of the reverse β-oxidation pathway in Corynebacterium glutamicum for production of adipic acid.

Authors:  Jae Ho Shin; Aaron John Christian Andersen; Puck Achterberg; Lisbeth Olsson
Journal:  Microb Cell Fact       Date:  2021-08-04       Impact factor: 5.328
  8 in total

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