Renan B Domingues 1 , Halina Duarte 2 , Natália P Rocha 3 , Antonio L Teixeira 4 Show Affiliations »
Abstract
BACKGROUND AND OBJECTIVES: The pathophysiology of tension-type headache is not well understood. Increased peripheral levels of pro-inflammatory cytokines may act as mediators of several chronic pain disorders. The aim of the present study was to investigate the peripheral levels of chemokines in patients with tension-type headache. METHODS: This was a cross sectional study evaluating serum levels of chemokines in age and sex-matched tension-type headache patients, ictally and interictally, and control participants. Beck Depression and Anxiety Inventories were recorded. Serum levels of monocyte chemoattractant protein-1, macrophage inflammatory protein 1α, regulated on activation, normal T cell expressed and secreted, eotaxin, eotaxin-2, interleukin-8, interferon gamma induced protein-10 were measured by enzyme-linked immunosorbent assay. RESULTS: A total of 96 participants (48 tension-type headache, 48 controls) were included. Interleukin-8 levels were significantly increased in patients with tension-type headache when compared to controls (413.8 (123.4-1756.3) and 329 (107.8-955.6), respectively, P = 0.025). Anxiety and depression scores were higher in patients with tension-type headache but interleukin-8 increase in tension-type headache patients persisted after controlling for anxiety and depression symptoms. Patients with headache at the time of assessment had increased monocyte chemoattractant protein-1 levels when compared with patients without headache (2809.3 (1101-6122.2) and 1630.2 (669.3-31056.8), respectively P = 0.026). Patients with episodic and chronic tension-type headache had no significant differences in serum chemokines levels. CONCLUSION: Interleukin-8 was increased in tension-type headache and monocyte chemoattractant protein-1 was higher in tension-type headache patients with headache, suggesting that pro-inflammatory mechanisms may participate in tension-type headache pathophysiology. © International Headache Society 2014.
BACKGROUND AND OBJECTIVES: The pathophysiology of tension-type headache is not well understood. Increased peripheral levels of pro-inflammatory cytokines may act as mediators of several chronic pain disorders . The aim of the present study was to investigate the peripheral levels of chemokines in patients with tension-type headache . METHODS: This was a cross sectional study evaluating serum levels of chemokines in age and sex-matched tension-type headache patients , ictally and interictally, and control participants . Beck Depression and Anxiety Inventories were recorded. Serum levels of monocyte chemoattractant protein-1 , macrophage inflammatory protein 1α, regulated on activation, normal T cell expressed and secreted, eotaxin , eotaxin-2 , interleukin-8 , interferon gamma induced protein-10 were measured by enzyme-linked immunosorbent assay. RESULTS: A total of 96 participants (48 tension-type headache , 48 controls) were included. Interleukin-8 levels were significantly increased in patients with tension-type headache when compared to controls (413.8 (123.4-1756.3) and 329 (107.8-955.6), respectively, P = 0.025). Anxiety and depression scores were higher in patients with tension-type headache but interleukin-8 increase in tension-type headache patients persisted after controlling for anxiety and depression symptoms . Patients with headache at the time of assessment had increased monocyte chemoattractant protein-1 levels when compared with patients without headache (2809.3 (1101-6122.2) and 1630.2 (669.3-31056.8), respectively P = 0.026). Patients with episodic and chronic tension-type headache had no significant differences in serum chemokines levels. CONCLUSION: Interleukin-8 was increased in tension-type headache and monocyte chemoattractant protein-1 was higher in tension-type headache patients with headache , suggesting that pro-inflammatory mechanisms may participate in tension-type headache pathophysiology. © International Headache Society 2014.
Entities: Disease
Gene
Species
Keywords:
Tension-type headache; anxiety; chemokines; chronic tension-type headache; depression; episodic tension-type headache; inflammation
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Year: 2014
PMID： 25416323 DOI： 10.1177/0333102414559734
Source DB: PubMed Journal: Cephalalgia ISSN： 0333-1024 Impact factor: 6.292