Literature DB >> 25414414

Characteristics and quantities of HIV host cells in human genital tract secretions.

Joseph A Politch1, Jai Marathe2, Deborah J Anderson3.   

Abstract

Human immunodeficiency virus (HIV)-infected leukocytes have been detected in genital secretions from HIV-infected men and women and may play an important role in the sexual transmission of HIV. However, they have been largely overlooked in studies on mechanisms of HIV transmission and in the design and testing of HIV vaccine and microbicide candidates. This article describes the characteristics and quantities of leukocytes in male and female genital secretions under various conditions and also reviews evidence for the involvement of HIV-infected cells in both horizontal and vertical cell-associated HIV transmission. Additional research is needed in this area to better target HIV prevention strategies.
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  AIDS; HIV; cell-associated; infected leukocytes; mucosal; rectum; semen; transmission; vagina

Mesh：

Year:  2014        PMID： 25414414      PMCID： PMC4303079          DOI： 10.1093/infdis/jiu390

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


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Review 3.  Targeting Trojan Horse leukocytes for HIV prevention.

Authors:  Deborah J Anderson; Joseph A Politch; Adam M Nadolski; Caitlin D Blaskewicz; Jeffrey Pudney; Kenneth H Mayer
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4.  Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone.

Authors:  Jeffrey Pudney; Alison J Quayle; Deborah J Anderson
Journal:  Biol Reprod       Date:  2005-08-10       Impact factor: 4.285

5.  Selenium deficiency is associated with shedding of HIV-1--infected cells in the female genital tract.

Authors:  J M Baeten; S B Mostad; M P Hughes; J Overbaugh; D D Bankson; K Mandaliya; J O Ndinya-Achola; J J Bwayo; J K Kreiss
Journal:  J Acquir Immune Defic Syndr       Date:  2001-04-01       Impact factor: 3.731

6.  Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission.

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Journal:  J Infect Dis       Date:  2004-10-07       Impact factor: 5.226

7.  Selective transmigration of monocyte-associated HIV-1 across a human cervical monolayer and its modulation by seminal plasma.

Authors:  Philip Lawrence; Didier Portran; Rachel Terrasse; Sabine Palle; Thomas Olivier; Jacques Fantini; Thomas Bourlet; Bruno Pozzetto; Olivier Delezay
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8.  Virus excretion in the cervicovaginal secretions of pregnant and nonpregnant HIV-infected women.

Authors:  Y Hénin; L Mandelbrot; R Henrion; R Pradinaud; J P Coulaud; L Montagnier
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1993-01

9.  Chemotactic activity of urethral secretions in men with urethritis and the effect of treatment.

Authors:  D A Lomas; D Natin; R A Stockley; M Shahmanesh
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10.  Detection of monocyte chemotactic and activating factor (MCAF) and interleukin (IL)-6 in human seminal plasma and effect of leukospermia on these cytokine levels.

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2.  Monocytes but Not Lymphocytes Carrying HIV-1 on Their Surface Transmit Infection to Human Tissue Ex Vivo.

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6.  Experimental Models to Study HIV Latency Reversal from Male Genital Myeloid Cells.

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7.  HIV-1 is undetectable in preejaculatory secretions from HIV-1-infected men on suppressive HAART.

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8.  Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness.

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9.  JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1.

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Review 10.  Systemic and topical use of monoclonal antibodies to prevent the sexual transmission of HIV.

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