Dae Seung Lee1, Hee Kyung Yang1, Jae Hyoung Kim2, Jeong-Min Hwang1. 1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. 2. Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Abstract
PURPOSE: To infer the pathogenic mechanism of congenital superior oblique palsy (SOP) by evaluating trochlear nerve diameter (CN4D) and superior oblique muscle (SO) volume in patients with congenital SOP. METHODS: The medical records of 125 patients diagnosed with unilateral congenital SOP and 34 age-matched healthy controls were reviewed retrospectively. Using thin-section high-resolution magnetic resonance imaging, we evaluated the presence of the trochlear nerve, CN4D, SO volume, and their relationship. RESULTS: Of the 125 patients with congenital SOP, 87 showed absence of the trochlear nerve (n = 87, 70%, absent group) and 38 showed bilateral presence of the trochlear nerve (n = 38, 30%, present group). The nonparetic side CN4D was smaller than controls in the absent group (P = 0.001), and larger than controls in the present group (P = 0.001). Trochlear nerve diameter positively correlated with SO volume in controls (P = 0.014, R(2) = 0.174) and in the nonparetic sides of congenital SOP (present group P = 0.023, R(2) = 0.135; absent group, P = 0.008, R(2) = 0.079). The paretic side SO volume did not show a linear correlation between CN4D and SO volume in the present group (P = 0.243). CONCLUSIONS: In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: To infer the pathogenic mechanism of congenital superior oblique palsy (SOP) by evaluating trochlear nerve diameter (CN4D) and superior oblique muscle (SO) volume in patients with congenital SOP. METHODS: The medical records of 125 patients diagnosed with unilateral congenital SOP and 34 age-matched healthy controls were reviewed retrospectively. Using thin-section high-resolution magnetic resonance imaging, we evaluated the presence of the trochlear nerve, CN4D, SO volume, and their relationship. RESULTS: Of the 125 patients with congenital SOP, 87 showed absence of the trochlear nerve (n = 87, 70%, absent group) and 38 showed bilateral presence of the trochlear nerve (n = 38, 30%, present group). The nonparetic side CN4D was smaller than controls in the absent group (P = 0.001), and larger than controls in the present group (P = 0.001). Trochlear nerve diameter positively correlated with SO volume in controls (P = 0.014, R(2) = 0.174) and in the nonparetic sides of congenital SOP (present group P = 0.023, R(2) = 0.135; absent group, P = 0.008, R(2) = 0.079). The paretic side SO volume did not show a linear correlation between CN4D and SO volume in the present group (P = 0.243). CONCLUSIONS: In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Entities:
Keywords:
congenital superior oblique palsy; superior oblique muscle; trochlear nerve