Literature DB >> 2541307

Localization by insertion mutagenesis of a virulence-associated region on the Salmonella typhimurium 96 kilobase pair plasmid.

M Rhen1, M Virtanen, P H Mäkelä.   

Abstract

The virulence-associated plasmid pEX102 of Salmonella typhimurium line TML R66 was tagged with the transposon Tn5 and the virulence of the mutants obtained was assayed in the mouse salmonellosis model. Out of 36 independent insertion mutants tested two isolates had clearly reduced virulence in (CBA x C57B1/6)F1 mice. The corresponding Tn5 elements were positioned on the restriction endonuclease map of pEX102 and found to be some 4 kilobases apart (kb) on the 96 kb virulence plasmid.

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Year:  1989        PMID： 2541307     DOI： 10.1016/0882-4010(89)90018-1

Source DB:  PubMed          Journal:  Microb Pathog        ISSN： 0882-4010            Impact factor:   3.738


  8 in total

1.  Genetic and DNA sequence analysis of the Salmonella typhimurium virulence plasmid gene encoding the 28,000-molecular-weight protein.

Authors:  P A Gulig; V A Chiodo
Journal:  Infect Immun       Date:  1990-08       Impact factor: 3.441

2.  Molecular mechanism of the regulation of expression of plasmid-encoded mouse bacteremia (mba) genes in Salmonella serovar Choleraesuis.

Authors:  H Matsui; A Abe; S Suzuki; M Kijima; Y Tamura; M Nakamura; K Kawahara; H Danbara
Journal:  Mol Gen Genet       Date:  1993-01

3.  Role of sigma factor RpoS in initial stages of Salmonella typhimurium infection.

Authors:  C A Nickerson; R Curtiss
Journal:  Infect Immun       Date:  1997-05       Impact factor: 3.441

4.  Virulence plasmid-borne spvB and spvC genes can replace the 90-kilobase plasmid in conferring virulence to Salmonella enterica serovar Typhimurium in subcutaneously inoculated mice.

Authors:  H Matsui; C M Bacot; W A Garlington; T J Doyle; S Roberts; P A Gulig
Journal:  J Bacteriol       Date:  2001-08       Impact factor: 3.490

5.  The Salmonella typhimurium virulence plasmid encodes a positive regulator of a plasmid-encoded virulence gene.

Authors:  A L Caldwell; P A Gulig
Journal:  J Bacteriol       Date:  1991-11       Impact factor: 3.490

6.  Evidence for functional polymorphism of the spvR gene regulating virulence gene expression in Salmonella.

Authors:  S Taira; P Heiskanen; R Hurme; H Heikkilä; P Riikonen; M Rhen
Journal:  Mol Gen Genet       Date:  1995-02-20

7.  Characterization of translation termination mutations in the spv operon of the Salmonella virulence plasmid pSDL2.

Authors:  C Roudier; J Fierer; D G Guiney
Journal:  J Bacteriol       Date:  1992-10       Impact factor: 3.490

8.  Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica.

Authors:  Sofia Eriksson Ygberg; Mark O Clements; Anne Rytkönen; Arthur Thompson; David W Holden; Jay C D Hinton; Mikael Rhen
Journal:  Infect Immun       Date:  2006-02       Impact factor: 3.441
  8 in total

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