Fang Quan1, Qian Zhao, Yuan Shao, Honghui Li, Ruimin Zhao. 1. Department of Otorhinolaryngology-Head Neck Surgery, First Affiliated of Xi'an Jiao Tong University, Xi'an 710061, China. E-mail: quanfang2013@163.com.
Abstract
OBJECTIVE: To study the radiosensitizing effect of resveratrol on human hypo pharyngeal squamous cell carcinoma (FaDu) cells in nude mice. METHODS: Forty-three nude mice bearing FaDu cell xenografts were randomized into control group, radiotherapy (12 Gy) group, resveratrol treatment (50 mg/kg) group, and radiotherapy plus resveratrol treatment group. After corresponding treatments, the tumor volume in the mice was measured every 3 days, and the microvessel density (MVD) in the tumor was evaluated with CD31 immunofluorescence histochemical staining. RESULTS: The tumor volume and weight were the smallest in mice receiving radiotherapy plus resveratrol treatment (P<0.05) but comparable between those having resveratrol treatment alone and the control mice. Radiotherapy plus resveratrol treatment resulted in a tumor inhibition rate of 76.64% and a significantly decreased MVD in the tumor compared with the other 3 groups. CONCLUSION: Resveratrol can produce a radiosensitizing effect on human hypopharyngeal carcinoma in nude mice.
OBJECTIVE: To study the radiosensitizing effect of resveratrol on humanhypo pharyngeal squamous cell carcinoma (FaDu) cells in nude mice. METHODS: Forty-three nude mice bearing FaDu cell xenografts were randomized into control group, radiotherapy (12 Gy) group, resveratrol treatment (50 mg/kg) group, and radiotherapy plus resveratrol treatment group. After corresponding treatments, the tumor volume in the mice was measured every 3 days, and the microvessel density (MVD) in the tumor was evaluated with CD31 immunofluorescence histochemical staining. RESULTS: The tumor volume and weight were the smallest in mice receiving radiotherapy plus resveratrol treatment (P<0.05) but comparable between those having resveratrol treatment alone and the control mice. Radiotherapy plus resveratrol treatment resulted in a tumor inhibition rate of 76.64% and a significantly decreased MVD in the tumor compared with the other 3 groups. CONCLUSION:Resveratrol can produce a radiosensitizing effect on humanhypopharyngeal carcinoma in nude mice.