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Literature DB >> 25412939

Long noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer.

Abstract

Pancreatic cancer (PC) is the fourth leading cause of cancer-related mortalities in the USA and the sixth leading cause of mortality in China. Recent studies have shown that lncRNAs play important roles in carcinogenesis. The aim of this study was to explore the role of lncRNA HULC in PC. Quantitative real-time PCR was performed to investigate the expression of HULC in tumor tissues and corresponding normal tissues from 304 patients with PC. The higher expression of HULC was significantly correlated with large tumor size, advanced lymph node metastasis and vascular invasion. Multivariate analyses revealed that HULC expression served as an independent predictor for overall survival (P = 0.032). Further experiments revealed that HULC knockdown significantly repressed cell proliferation of PC in vitro. In conclusion, our results suggest that HULC may serve as a candidate prognostic biomarker through growth regulation in human PC.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 25412939 DOI： 10.1007/s12032-014-0346-4

Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064

24 in total

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Journal: Cancer Lett Date: 2013-02-14 Impact factor: 8.679

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72 in total

Review 1. Noncoding RNAs and pancreatic cancer.

Authors: Juan-Fei Peng; Yan-Yan Zhuang; Feng-Ting Huang; Shi-Neng Zhang
Journal: World J Gastroenterol Date: 2016-01-14 Impact factor: 5.742

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Journal: Surg Clin North Am Date: 2015-07-23 Impact factor: 2.741

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Authors: Wei Peng; Guoqiu Wu; Hong Fan; Jianzhong Wu; Jifeng Feng
Journal: Tumour Biol Date: 2015-04-03

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Authors: Xiao-Hui Sun; Li-Bin Yang; Xiao-Lin Geng; Ran Wang; Zhi-Chang Zhang
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Authors: Qiuyun Yu; Xinfeng Zhou; Qing Xia; Jia Shen; Jia Yan; Jiuting Zhu; Xiang Li; Ming Shu
Journal: Am J Transl Res Date: 2016-12-15 Impact factor: 4.060

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Authors: Wei Peng; Jianzhong Wu; Jifeng Feng
Journal: Clin Exp Med Date: 2015-10-16 Impact factor: 3.984