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Literature DB >> 25412896

Efficient synthesis and evaluation of antitumor activities of novel functionalized 1,8-naphthyridine derivatives.

Lei Fu¹, Xian Feng, Jian-Jun Wang, Zhan Xun, Jun-Die Hu, Juan-Juan Zhang, Yan-Wei Zhao, Zhi-Bin Huang, Da-Qing Shi.

Abstract

An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.

Entities: Chemical Disease

Keywords: 1,8-naphthyridine; antitumor activity; cascade reaction; chromeno[2,3-b]quinoline

Mesh：

Substances：

Year: 2014 PMID： 25412896 DOI： 10.1021/co500120b

Source DB: PubMed Journal: ACS Comb Sci ISSN： 2156-8944 Impact factor: 3.784

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Cited

4 in total

1. The regioselective one-pot four-component synthesis of novel functionalized 4H-pyrano[2, 3-b]quinoline derivatives using DABCO as a homogeneous organocatalyst.

Authors: Masumeh Heydari; Ali Asghar Mohammadi; Mohammadreza Mosleh
Journal: Mol Divers Date: 2022-09-07 Impact factor: 3.364

Efficient synthesis and evaluation of antitumor activities of novel functionalized 1,8-naphthyridine derivatives.

1. The regioselective one-pot four-component synthesis of novel functionalized 4H-pyrano[2, 3-b]quinoline derivatives using DABCO as a homogeneous organocatalyst.

2. Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents.

3. Fluorescent Zn^II Chemosensor Mediated by a 1,8-Naphthyridine Derivative and It's Photophysical Properties.

4. Discovery of 8-Amino-Substituted 2-Phenyl-2,7-Naphthyridinone Derivatives as New c-Kit/VEGFR-2 Kinase Inhibitors.

Efficient synthesis and evaluation of antitumor activities of novel functionalized 1,8-naphthyridine derivatives.

1. The regioselective one-pot four-component synthesis of novel functionalized 4H-pyrano[2, 3-b]quinoline derivatives using DABCO as a homogeneous organocatalyst.

2. Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents.

3. Fluorescent ZnII Chemosensor Mediated by a 1,8-Naphthyridine Derivative and It's Photophysical Properties.

4. Discovery of 8-Amino-Substituted 2-Phenyl-2,7-Naphthyridinone Derivatives as New c-Kit/VEGFR-2 Kinase Inhibitors.

3. Fluorescent Zn^II Chemosensor Mediated by a 1,8-Naphthyridine Derivative and It's Photophysical Properties.