Literature DB >> 25412663

Producing GM-CSF: a unique T helper subset?

Dietmar Herndler-Brandstetter1, Richard A Flavell2.   

Abstract

GM-CSF-producing helper T cells have previously been identified to serve a nonredundant function in the initiation of autoimmune inflammation. An article by Sheng et al. recently published by Cell Research now suggests that the differentiation program of GM-CSF-producing cells from naïve CD4 T cells is distinct from that of Th1 and Th17 cells, and is regulated by the IL-7-STAT5 axis.

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Year:  2014        PMID： 25412663      PMCID： PMC4260353          DOI： 10.1038/cr.2014.155

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  9 in total

1.  The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

Authors:  Mohamed El-Behi; Bogoljub Ciric; Hong Dai; Yaping Yan; Melissa Cullimore; Farinaz Safavi; Guang-Xian Zhang; Bonnie N Dittel; Abdolmohamad Rostami
Journal:  Nat Immunol       Date:  2011-04-24       Impact factor: 25.606

2.  RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

Authors:  Laura Codarri; Gabor Gyülvészi; Vinko Tosevski; Lysann Hesske; Adriano Fontana; Laurent Magnenat; Tobias Suter; Burkhard Becher
Journal:  Nat Immunol       Date:  2011-04-24       Impact factor: 25.606

3.  Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.

Authors:  Li-Fen Lee; Kathryn Logronio; Guang Huan Tu; Wenwu Zhai; Irene Ni; Li Mei; Jeanette Dilley; Jessica Yu; Arvind Rajpal; Colleen Brown; Charles Appah; Sherman Michael Chin; Bora Han; Timothy Affolter; John C Lin
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-25       Impact factor: 11.205

Review 4.  IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia.

Authors:  Daniel Ribeiro; Alice Melão; João T Barata
Journal:  Adv Biol Regul       Date:  2012-10-16

Review 5.  Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells.

Authors:  John J O'Shea; William E Paul
Journal:  Science       Date:  2010-02-26       Impact factor: 47.728

6.  Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.

Authors:  Arian Laurence; Cristina M Tato; Todd S Davidson; Yuka Kanno; Zhi Chen; Zhengju Yao; Rebecca B Blank; Françoise Meylan; Richard Siegel; Lothar Hennighausen; Ethan M Shevach; John J O'shea
Journal:  Immunity       Date:  2007-03       Impact factor: 31.745

7.  IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.

Authors:  Rebecca Noster; René Riedel; Mir-Farzin Mashreghi; Helena Radbruch; Lutz Harms; Claudia Haftmann; Hyun-Dong Chang; Andreas Radbruch; Christina E Zielinski
Journal:  Sci Transl Med       Date:  2014-06-18       Impact factor: 17.956

8.  CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.

Authors:  Thomas R Malek; Aixin Yu; Vladimir Vincek; Paul Scibelli; Lin Kong
Journal:  Immunity       Date:  2002-08       Impact factor: 31.745

9.  STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation.

Authors:  Wanqiang Sheng; Fan Yang; Yi Zhou; Henry Yang; Pey Yng Low; David Michael Kemeny; Patrick Tan; Akira Moh; Mark H Kaplan; Yongliang Zhang; Xin-Yuan Fu
Journal:  Cell Res       Date:  2014-11-21       Impact factor: 25.617
  9 in total
  13 in total

1.  Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes.

Authors:  Caroline Stienne; Michaël F Michieletto; Mehdi Benamar; Nadège Carrié; Isabelle Bernard; Xuan-Hung Nguyen; Yannick Lippi; Fanny Duguet; Roland S Liblau; Stephen M Hedrick; Abdelhadi Saoudi; Anne S Dejean
Journal:  Immunity       Date:  2016-10-11       Impact factor: 31.745

Review 2.  T cell responses in the central nervous system.

Authors:  Thomas Korn; Axel Kallies
Journal:  Nat Rev Immunol       Date:  2017-01-31       Impact factor: 53.106

3.  Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.

Authors:  Igal Ifergan; Todd S Davidson; Hania Kebir; Dan Xu; Daphne Palacios-Macapagal; Jennifer Cann; Jane M Rodgers; Zoe N Hunter; Camille L Pittet; Sara Beddow; Clare A Jones; Alexandre Prat; Matthew A Sleeman; Stephen D Miller
Journal:  J Autoimmun       Date:  2017-06-20       Impact factor: 7.094

Review 4.  Repositioning TH cell polarization from single cytokines to complex help.

Authors:  Selma Tuzlak; Florent Ginhoux; Thomas Korn; Burkhard Becher; Anne S Dejean; Matteo Iannacone; Francisco J Quintana; Ari Waisman
Journal:  Nat Immunol       Date:  2021-09-20       Impact factor: 25.606

5.  A T Cell View of the Bone Marrow.

Authors:  Adriana Bonomo; Ana Carolina Monteiro; Triciana Gonçalves-Silva; Eric Cordeiro-Spinetti; Rômulo Gonçalves Galvani; Alex Balduino
Journal:  Front Immunol       Date:  2016-05-17       Impact factor: 7.561

6.  T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis.

Authors:  Richard T Robinson
Journal:  mBio       Date:  2017-12-12       Impact factor: 7.867

7.  Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes.

Authors:  Jonas Bystrom; Felix I Clanchy; Taher E Taher; Mohammed M Al-Bogami; Hawzheen A Muhammad; Saba Alzabin; Pamela Mangat; Ali S Jawad; Richard O Williams; Rizgar A Mageed
Journal:  Clin Rev Allergy Immunol       Date:  2017-10       Impact factor: 8.667

8.  CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells.

Authors:  S M Restorick; L Durant; S Kalra; G Hassan-Smith; E Rathbone; M R Douglas; S J Curnow
Journal:  Brain Behav Immun       Date:  2017-03-20       Impact factor: 7.217

9.  Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation.

Authors:  Iva Xhangolli; Burak Dura; GeeHee Lee; Dongjoo Kim; Yang Xiao; Rong Fan
Journal:  Genomics Proteomics Bioinformatics       Date:  2019-06-20       Impact factor: 7.691

Review 10.  Potential for Targeting Myeloid Cells in Controlling CNS Inflammation.

Authors:  Igal Ifergan; Stephen D Miller
Journal:  Front Immunol       Date:  2020-10-06       Impact factor: 7.561
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