Literature DB >> 2541130

Production of platelet-derived growth factorlike protein(s) by a human carcinoma cell line.

K A O'Donnell1, M E Condon, A W Hamburger.   

Abstract

Human adrenal carcinoma cells (SW-13) produce and secrete autocrine growth factors. We now report that these cells secrete a factor that is biologically related to platelet-derived growth factor (PDGF). Serum-free medium conditioned by SW-13 cells stimulated incorporation of tritiated thymidine into DNA by quiescent Balb/c 3T3 cells in the presence of platelet-poor plasma. The conditioned media also competed with 125I-labeled PDGF for binding to PDGF receptors on human fibroblasts. Hybridization studies identified mRNA transcripts for PDGF-2/sis chains in logarithmically growing SW-13 cells. These data suggest secretion of PDGF-like mitogens by SW-13 cells.

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Year:  1989        PMID： 2541130     DOI： 10.1007/bf02624602

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol        ISSN： 0883-8364


  21 in total

1.  Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines.

Authors:  R Peres; C Betsholtz; B Westermark; C H Heldin
Journal:  Cancer Res       Date:  1987-07-01       Impact factor: 12.701

2.  Expression of multiple growth factors in a human lung cancer cell line.

Authors:  C Betsholtz; J Bergh; M Bywater; M Pettersson; A Johnsson; C H Heldin; R Ohlsson; T J Knott; J Scott; G I Bell
Journal:  Int J Cancer       Date:  1987-04-15       Impact factor: 7.396

3.  Structural and functional identification of platelet-derived growth factor-like proteins produced by mammalian cells.

Authors:  H N Antoniades; P Pantazis
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

4.  Two classes of PDGF receptor recognize different isoforms of PDGF.

Authors:  C E Hart; J W Forstrom; J D Kelly; R A Seifert; R A Smith; R Ross; M J Murray; D F Bowen-Pope
Journal:  Science       Date:  1988-06-10       Impact factor: 47.728

5.  Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation.

Authors:  C Betsholtz; B Westermark; B Ek; C H Heldin
Journal:  Cell       Date:  1984-12       Impact factor: 41.582

6.  A glioma-derived analog to platelet-derived growth factor: demonstration of receptor competing activity and immunological crossreactivity.

Authors:  M Nistér; C H Heldin; A Wasteson; B Westermark
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

7.  Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: resemblance with platelet-derived growth factor.

Authors:  C H Heldin; B Westermark; A Wasteson
Journal:  J Cell Physiol       Date:  1980-11       Impact factor: 6.384

8.  Autocrine growth factors for human tumor clonogenic cells.

Authors:  A W Hamburger; C P White
Journal:  Int J Cell Cloning       Date:  1985-11

9.  Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis.

Authors:  S G Devare; E P Reddy; J D Law; K C Robbins; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

10.  Constitutive production of platelet-derived growth factor-like proteins by human prostate carcinoma cell lines.

Authors:  N M Sitaras; E Sariban; M Bravo; P Pantazis; H N Antoniades
Journal:  Cancer Res       Date:  1988-04-01       Impact factor: 12.701
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