Cécilia Samieri1, Qi Sun1, Mary K Townsend1, Eric B Rimm1, Francine Grodstein1. 1. From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (CS, QS, MKT, EBR, and FG); Institut National pour la Santé et la Recherche Médicale (INSERM), Centre INSERM U897-Epidémiologie-Biostatistiques and Université de Bordeaux, Bordeaux, France (CS); and the Departments of Epidemiology (EBR and FG) and Nutrition (QS and EBR), Harvard School of Public Health, Boston, MA.
Abstract
BACKGROUND: Dietary flavonoids have been related to lower risks of various chronic diseases, but it is unclear whether flavonoid intake in midlife helps to maintain good health and wellbeing in aging. OBJECTIVE: We examined the relation of flavonoid intake in midlife with the prevalence of healthy aging. DESIGN: We included 13,818 women from the Nurses' Health Study with dietary data and no major chronic diseases in 1984-1986 when they were aged in their late 50s (median age: 59 y); all women provided information on multiple aspects of aging an average of 15 y later. Intakes of 6 major flavonoid subclasses in midlife were ascertained on the basis of averaged intakes of flavonoid-rich foods from 2 food-frequency questionnaires (1984-1986). We defined healthy compared with usual aging as of age 70 y; healthy aging was based on survival to ≥70 y with maintenance of 4 health domains (no major chronic diseases or major impairments in cognitive or physical function or mental health). RESULTS: Of women who survived until ≥70 y of age, 1517 women (11.0%) met our criteria for healthy aging. Compared with women in the lowest quintile of intake, women in the highest quintile of intake of several flavonoid subclasses at midlife had greater odds of healthy aging. After multivariable adjustment, ORs were as follows: flavones, 1.32 (95% CI: 1.10, 1.58); flavanone, 1.28 (95% CI: 1.08, 1.53); anthocyanin, 1.25 (95% CI: 1.04, 1.50); and flavonol, 1.18 (95% CI: 0.98, 1.42) (all P-trend ≤ 0.02). Consistently, greater intakes of major sources of these flavonoids (i.e., oranges, berries, onions, and apples) were associated with increased odds of healthy aging. We showed no association with flavan-3-ol monomers (P-trend = 0.80) or polymers (P-trend = 0.63). CONCLUSION: Higher intake of flavonoids at midlife, specifically flavones, flavanones, anthocyanins, and flavonols, is associated with greater likelihood of health and wellbeing in individuals surviving to older ages.
BACKGROUND: Dietary flavonoids have been related to lower risks of various chronic diseases, but it is unclear whether flavonoid intake in midlife helps to maintain good health and wellbeing in aging. OBJECTIVE: We examined the relation of flavonoid intake in midlife with the prevalence of healthy aging. DESIGN: We included 13,818 women from the Nurses' Health Study with dietary data and no major chronic diseases in 1984-1986 when they were aged in their late 50s (median age: 59 y); all women provided information on multiple aspects of aging an average of 15 y later. Intakes of 6 major flavonoid subclasses in midlife were ascertained on the basis of averaged intakes of flavonoid-rich foods from 2 food-frequency questionnaires (1984-1986). We defined healthy compared with usual aging as of age 70 y; healthy aging was based on survival to ≥70 y with maintenance of 4 health domains (no major chronic diseases or major impairments in cognitive or physical function or mental health). RESULTS: Of women who survived until ≥70 y of age, 1517 women (11.0%) met our criteria for healthy aging. Compared with women in the lowest quintile of intake, women in the highest quintile of intake of several flavonoid subclasses at midlife had greater odds of healthy aging. After multivariable adjustment, ORs were as follows: flavones, 1.32 (95% CI: 1.10, 1.58); flavanone, 1.28 (95% CI: 1.08, 1.53); anthocyanin, 1.25 (95% CI: 1.04, 1.50); and flavonol, 1.18 (95% CI: 0.98, 1.42) (all P-trend ≤ 0.02). Consistently, greater intakes of major sources of these flavonoids (i.e., oranges, berries, onions, and apples) were associated with increased odds of healthy aging. We showed no association with flavan-3-ol monomers (P-trend = 0.80) or polymers (P-trend = 0.63). CONCLUSION: Higher intake of flavonoids at midlife, specifically flavones, flavanones, anthocyanins, and flavonols, is associated with greater likelihood of health and wellbeing in individuals surviving to older ages.
Authors: Rikard Landberg; Qi Sun; Eric B Rimm; Aedin Cassidy; Augustin Scalbert; Christos S Mantzoros; Frank B Hu; Rob M van Dam Journal: J Nutr Date: 2011-02-16 Impact factor: 4.798
Authors: W C Willett; L Sampson; M J Stampfer; B Rosner; C Bain; J Witschi; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1985-07 Impact factor: 4.897
Authors: Pamela J Mink; Carolyn G Scrafford; Leila M Barraj; Lisa Harnack; Ching-Ping Hong; Jennifer A Nettleton; David R Jacobs Journal: Am J Clin Nutr Date: 2007-03 Impact factor: 7.045
Authors: Peter James; Eric S Kim; Laura D Kubzansky; Emily S Zevon; Claudia Trudel-Fitzgerald; Francine Grodstein Journal: Am J Prev Med Date: 2019-01 Impact factor: 5.043
Authors: Anna Vogiatzoglou; Angela A Mulligan; Amit Bhaniani; Marleen A H Lentjes; Alison McTaggart; Robert N Luben; Christian Heiss; Malte Kelm; Marc W Merx; Jeremy P E Spencer; Hagen Schroeter; Kay-Tee Khaw; Gunter G C Kuhnle Journal: Free Radic Biol Med Date: 2015-03-17 Impact factor: 7.376
Authors: Małgorzata Elżbieta Zujko; Anna Maria Witkowska; Anna Waśkiewicz; Iwona Mirończuk-Chodakowska Journal: Oxid Med Cell Longev Date: 2015-07-08 Impact factor: 6.543