OBJECTIVE: Depression is the most prevalent psychiatric disorder in persons with epilepsy (PWEs). Despite its major impact on quality of life and risk of suicide, most PWEs are not treated for depression. A current challenge in mental health care is how to close this treatment gap and increase access to psychological services. Psychological online interventions (POIs) have shown efficacy in improving depression among individuals without neurologic disorders. This pilot study aimed to assess the feasibility and efficacy of a psychological online intervention for depression (Deprexis) in PWEs who have symptoms of depression. METHODS:Participants with self-reported epilepsy and subjective complaints of depressive symptoms were randomized to an intervention condition (Deprexis) or to a waiting list control (WLC) condition. After 9 weeks, participants were invited to complete an online reassessment. RESULTS: Relative to the waiting list group, program users experienced a significant symptom decline on the Beck Depression Inventory - I (BDI-I, primary outcome) with a moderate effect size in the complete observations analysis and a small effect size in the intention-to-treat analysis. Furthermore, there was a significant improvement with a moderate effect size on the "energy/fatigue" subscale of the Quality of Life In Epilepsy Inventory - 31 (QOLIE-31). SIGNIFICANCE: The results of this trial suggest that POIs may be a feasible and beneficial tool for PWEs who have comorbid depressive symptoms. Wiley Periodicals, Inc.
RCT Entities:
OBJECTIVE:Depression is the most prevalent psychiatric disorder in persons with epilepsy (PWEs). Despite its major impact on quality of life and risk of suicide, most PWEs are not treated for depression. A current challenge in mental health care is how to close this treatment gap and increase access to psychological services. Psychological online interventions (POIs) have shown efficacy in improving depression among individuals without neurologic disorders. This pilot study aimed to assess the feasibility and efficacy of a psychological online intervention for depression (Deprexis) in PWEs who have symptoms of depression. METHODS:Participants with self-reported epilepsy and subjective complaints of depressive symptoms were randomized to an intervention condition (Deprexis) or to a waiting list control (WLC) condition. After 9 weeks, participants were invited to complete an online reassessment. RESULTS: Relative to the waiting list group, program users experienced a significant symptom decline on the Beck Depression Inventory - I (BDI-I, primary outcome) with a moderate effect size in the complete observations analysis and a small effect size in the intention-to-treat analysis. Furthermore, there was a significant improvement with a moderate effect size on the "energy/fatigue" subscale of the Quality of Life In Epilepsy Inventory - 31 (QOLIE-31). SIGNIFICANCE: The results of this trial suggest that POIs may be a feasible and beneficial tool for PWEs who have comorbid depressive symptoms. Wiley Periodicals, Inc.
Authors: Jan Philipp Klein; Thomas Berger; Johanna Schröder; Christina Späth; Björn Meyer; Franz Caspar; Wolfgang Lutz; Alice Arndt; Wolfgang Greiner; Viola Gräfe; Martin Hautzinger; Kristina Fuhr; Matthias Rose; Sandra Nolte; Bernd Löwe; Gerhard Anderssoni; Eik Vettorazzi; Steffen Moritz; Fritz Hohagen Journal: Psychother Psychosom Date: 2016-05-27 Impact factor: 17.659
Authors: Rosa Michaelis; Venus Tang; Sarah J Nevitt; Janelle L Wagner; Avani C Modi; William Curt LaFrance; Laura H Goldstein; Milena Gandy; Rebecca Bresnahan; Kette Valente; Kirsten A Donald; Markus Reuber Journal: Cochrane Database Syst Rev Date: 2020-09-07
Authors: Rosa Michaelis; Venus Tang; Janelle L Wagner; Avani C Modi; William Curt LaFrance; Laura H Goldstein; Tobias Lundgren; Markus Reuber Journal: Cochrane Database Syst Rev Date: 2017-10-27
Authors: Björn Meyer; Mario Weiss; Martin Holtkamp; Stephan Arnold; Katja Brückner; Johanna Schröder; Franziska Scheibe; Yvonne Nestoriuc Journal: BMC Psychiatry Date: 2017-02-07 Impact factor: 3.630
Authors: Johanna Schröder; Thomas Berger; Stefan Westermann; Jan Philipp Klein; Steffen Moritz Journal: Dialogues Clin Neurosci Date: 2016-06 Impact factor: 5.986
Authors: Milena Gandy; Avani C Modi; Janelle L Wagner; W Curt LaFrance; Markus Reuber; Venus Tang; Kette D Valente; Laura H Goldstein; Kirsten A Donald; Genevieve Rayner; Rosa Michaelis Journal: Epilepsia Open Date: 2021-02-08