Literature DB >> 2541019

Growth stimulatory effect of pancreatic spasmolytic polypeptide on cultured colon and breast tumor cells.

N M Hoosein1, L Thim, K H Jørgensen, M G Brattain.   

Abstract

The effects of a novel polypeptide, pancreatic spasmolytic polypeptide (PSP) on a colon carcinoma cell line (HCT 116) were examined. PSP stimulated the incorporation of [3H]thymidine into HCT 116 cells as well as cell proliferation in a dose-dependent manner. Maximal increase in [3H]thymidine incorporation of 50-60% occurred at 3-300 microM PSP. The VIP-mediated-increase in cAMP levels was reduced by PSP at greater than 1 microM concentrations. PSP is highly homologous to the estrogen-induced pS2 protein in MCF-7 breast cancer cells. We find that PSP also enhanced [3H]thymidine incorporation in MCF-7 cells. These findings indicate for the first time that PSP has growth stimulatory properties.

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Year:  1989        PMID： 2541019     DOI： 10.1016/0014-5793(89)81357-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  22 in total

1.  Trefoil factor family peptide 2 acts pro-proliferative and pro-apoptotic in the murine retina.

Authors:  Adnana N Paunel-Görgülü; Andreas G Franke; Friedrich P Paulsen; Nicole Dünker
Journal:  Histochem Cell Biol       Date:  2011-04-22       Impact factor: 4.304

2.  Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.

Authors:  S Suemori; K Lynch-Devaney; D K Podolsky
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

3.  TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury.

Authors:  James J Farrell; Douglas Taupin; Theodore J Koh; Duan Chen; Chun-Mei Zhao; Daniel K Podolsky; Timothy C Wang
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

Review 4.  Healing the epithelium: solving the problem from two sides.

Authors:  D K Podolsky
Journal:  J Gastroenterol       Date:  1997-02       Impact factor: 7.527

5.  Trefoil peptides and the gut.

Authors:  N A Wright
Journal:  Gut       Date:  1993-05       Impact factor: 23.059

6.  Natural gastrointestinal ulcer healing mechanism?

Authors:  R Williams; E N Ialani; G W Stamp
Journal:  J R Soc Med       Date:  1994-11       Impact factor: 5.344

7.  Hyperplastic polyps: a cell lineage which both synthesizes and secretes trefoil-peptides and has phenotypic similarity with the ulcer-associated cell lineage.

Authors:  A M Hanby; R Poulsom; S Singh; J Jankowski; D Hopwood; G Elia; L Rogers; K Patel; N A Wright
Journal:  Am J Pathol       Date:  1993-03       Impact factor: 4.307

8.  Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors.

Authors:  A De; D G Brown; M A Gorman; M Carr; M R Sanderson; P S Freemont
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

9.  Expression of trefoil peptides pS2 and human spasmolytic polypeptide in gastric metaplasia at the margin of duodenal ulcers.

Authors:  S Khulusi; A M Hanby; J M Marrero; P Patel; M A Mendall; S Badve; R Poulsom; G Elia; N A Wright; T C Northfield
Journal:  Gut       Date:  1995-08       Impact factor: 23.059

10.  cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis.

Authors:  H Itoh; M Tomita; H Uchino; T Kobayashi; H Kataoka; R Sekiya; Y Nawa
Journal:  Biochem J       Date:  1996-09-15       Impact factor: 3.857
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