Literature DB >> 2541013

Hormone-sensitive lipase is responsible for the neutral cholesterol ester hydrolase activity in macrophages.

C A Small1, J A Goodacre, S J Yeaman.   

Abstract

Anti-hormone-sensitive lipase (HSL) immunoglobulin selectively immunoprecipitates a single 84 kDa 32P-phosphoprotein from macrophage homogenates previously phosphorylated by cyclic AMP-dependent protein kinase in the presence of [gamma-32P]ATP-Mg. This immunoglobulin also completely removes the neutral cholesterol ester hydrolase activity from macrophage homogenates. These data demonstrate that HSL is responsible for the neutral cholesterol ester hydrolase activity in macrophages and hence plays a key role in cholesterol metabolism in these cells.

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Year:  1989        PMID： 2541013     DOI： 10.1016/0014-5793(89)81335-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

1.  Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity.

Authors:  J Osuga; S Ishibashi; T Oka; H Yagyu; R Tozawa; A Fujimoto; F Shionoiri; N Yahagi; F B Kraemer; O Tsutsumi; N Yamada
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

2.  Down-regulation of hormone-sensitive lipase in sterol ester-laden J774.2 macrophages.

Authors:  C A Jepson; J A Harrison; F B Kraemer; S J Yeaman
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

3.  Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363.

Authors:  Marlene Buchebner; Thomas Pfeifer; Nora Rathke; Prakash G Chandak; Achim Lass; Renate Schreiber; Adelheid Kratzer; Robert Zimmermann; Wolfgang Sattler; Harald Koefeler; Eleonore Fröhlich; Gerhard M Kostner; Ruth Birner-Gruenberger; Kyle P Chiang; Guenter Haemmerle; Rudolf Zechner; Sanja Levak-Frank; Benjamin Cravatt; Dagmar Kratky
Journal:  J Lipid Res       Date:  2010-07-12       Impact factor: 5.922

4.  Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.

Authors:  Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Motohiro Sekiya; Makiko Tajima; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Yoshiaki Tamura; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Michiyo Amemiya-Kudo; Yoshimi Nakagawa; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Journal:  J Biol Chem       Date:  2008-09-09       Impact factor: 5.157

5.  Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.

Authors:  Anton I Rosenbaum; Madalina Rujoi; Amy Y Huang; Hong Du; Gregory A Grabowski; Frederick R Maxfield
Journal:  Biochim Biophys Acta       Date:  2009-08-20

6.  Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.

Authors:  J Allen Crow; Brandy L Middleton; Abdolsamad Borazjani; M Jason Hatfield; Philip M Potter; Matthew K Ross
Journal:  Biochim Biophys Acta       Date:  2008-08-05

7.  Sterol-mediated regulation of hormone-sensitive lipase in 3T3-L1 adipocytes.

Authors:  Shinji Miura; Hiromi Nagura; Fusae Sawamura; Isao Tomita; Eiji Kawai; Norihiro Mochizuki; Masahiko Ikeda; Fredric B Kraemer; Takako Tomita
Journal:  Lipids       Date:  2003-07       Impact factor: 1.880

Review 8.  Hormone-sensitive lipase--new roles for an old enzyme.

Authors:  Stephen J Yeaman
Journal:  Biochem J       Date:  2004-04-01       Impact factor: 3.857

Review 9.  Macrophage cholesteryl ester mobilization and atherosclerosis.

Authors:  Shobha Ghosh; Bin Zhao; Jinghua Bie; Jingmei Song
Journal:  Vascul Pharmacol       Date:  2009-10-28       Impact factor: 5.773

10.  Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice.

Authors:  Bin Zhao; Jingmei Song; Woon N Chow; Richard W St Clair; Lawrence L Rudel; Shobha Ghosh
Journal:  J Clin Invest       Date:  2007-10       Impact factor: 14.808
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