INTRODUCTION: The cause of osteoarthritis is inflammation associated with production of proinflammatory cytokines, activation of matrix metalloproteinases, dysregulation of extracellular matrix, and weakening of mechanical cartilage integration. The joint damage is mediated by reactive oxygen species. Biomarkers influencing the course of the disease can be found in the peripheral blood. AIM OF THE STUDY: The aim of the study was to confirm whether total hip replacement due to osteoarthritis changes the levels of biochemical parameters associated with degenerative changes. MATERIAL AND METHODS: The study enrolled 34 patients qualified for total hip replacement. On the day of surgery, at day 10 after surgery and 6 weeks after surgery, blood was collected for analysis from the patients. Selected erythrocyte redox balance parameters were analyzed, i.e.: concentration of compounds reacting with thiobarbituric acid (TBARS), catalase activity, activity of superoxide dismutase and glutathione peroxidase and serum concentration of cytokines: IL6 and Il-1β/Il-1F2. CONCLUSION: Hip joint alloplasty leads to a reduction of inflammatory parameters and shifts the redox balance toward a reduced state.
INTRODUCTION: The cause of osteoarthritis is inflammation associated with production of proinflammatory cytokines, activation of matrix metalloproteinases, dysregulation of extracellular matrix, and weakening of mechanical cartilage integration. The joint damage is mediated by reactive oxygen species. Biomarkers influencing the course of the disease can be found in the peripheral blood. AIM OF THE STUDY: The aim of the study was to confirm whether total hip replacement due to osteoarthritis changes the levels of biochemical parameters associated with degenerative changes. MATERIAL AND METHODS: The study enrolled 34 patients qualified for total hip replacement. On the day of surgery, at day 10 after surgery and 6 weeks after surgery, blood was collected for analysis from the patients. Selected erythrocyte redox balance parameters were analyzed, i.e.: concentration of compounds reacting with thiobarbituric acid (TBARS), catalase activity, activity of superoxide dismutase and glutathione peroxidase and serum concentration of cytokines: IL6 and Il-1β/Il-1F2. CONCLUSION:Hip joint alloplasty leads to a reduction of inflammatory parameters and shifts the redox balance toward a reduced state.