Yi-Che Lee1,2, Shih-Yuan Hung1, Hao-Kuang Wang3,2, Chi-Wei Lin4, Hsi-Hao Wang1, Shih-Wei Chen5, Min-Yu Chang1, Li-Chun Ho1,2, Yi-Ting Chen1, Hung-Hsiang Liou6, Tsuen-Chiuan Tsai7, Shih-Hann Tseng8, Wei-Ming Wang9, Sheng-Hsiang Lin2, Yuan-Yow Chiou2,10. 1. Division of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan. 2. Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. 3. Department of Neurosurgery, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan. 4. Department of Medical Education, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan. 5. Department of Family Medicine, Hsinchu Cathay General Hospital, Hsinchu, Taiwan. 6. Division of Nephrology, Department of Medicine, Hsin-Jen Hospital, New Taipei City, Taiwan. 7. Department of Pediatrics, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan. 8. Hong-En Clinic, Kaohsiung, Taiwan. 9. Biostatistics Consulting Center, National Cheng Kung University Hospital, Tainan, Taiwan. 10. Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan.
Abstract
STUDY OBJECTIVES: Sleep apnea (SA) is characterized by apnea during sleep and is associated with cardiovascular diseases and an increase in all-cause mortality. Chronic kidney disease (CKD) is a global health problem that has placed a substantial burden on healthcare resources. However, the relationship between SA and the incidence of CKD is not clear. This study aimed to determine whether SA is an independent risk factor for the development of CKD. DESIGN: Retrospective cohort study. SETTING: National Health Insurance Research Database (NHIRD) of Taiwan. PATIENTS OR PARTICIPANTS: A total of 4,674 adult patients (age ≥ 30 y) in whom SA was newly diagnosed from 2000 to 2010 were included, together with 23,370 non-SA patients as the comparison group. The two groups were frequency-matched for sex, age, and year of receiving medical service. Each individual was followed until 2011. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: These two groups were monitored and observed for the occurrence of CKD. Patients with SA experienced a 1.94-fold increase (95% confidence interval [CI], 1.52-2.46; P < 0.001) in the incidence of CKD, which was independent of sex, age, and comorbid medical conditions. Additionally, they showed a 2.2-fold increase (95% CI, 1.31-3.69; P < 0.01) in the incidence of end-stage renal disease (ESRD). CONCLUSIONS: Patients with sleep apnea are at increased risk for chronic kidney disease and end-stage renal disease compared with the general population. As such, screening renal function and treatment of chronic kidney disease is an important issue in patients with sleep apnea.
STUDY OBJECTIVES:Sleep apnea (SA) is characterized by apnea during sleep and is associated with cardiovascular diseases and an increase in all-cause mortality. Chronic kidney disease (CKD) is a global health problem that has placed a substantial burden on healthcare resources. However, the relationship between SA and the incidence of CKD is not clear. This study aimed to determine whether SA is an independent risk factor for the development of CKD. DESIGN: Retrospective cohort study. SETTING: National Health Insurance Research Database (NHIRD) of Taiwan. PATIENTS OR PARTICIPANTS: A total of 4,674 adult patients (age ≥ 30 y) in whom SA was newly diagnosed from 2000 to 2010 were included, together with 23,370 non-SA patients as the comparison group. The two groups were frequency-matched for sex, age, and year of receiving medical service. Each individual was followed until 2011. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: These two groups were monitored and observed for the occurrence of CKD. Patients with SA experienced a 1.94-fold increase (95% confidence interval [CI], 1.52-2.46; P < 0.001) in the incidence of CKD, which was independent of sex, age, and comorbid medical conditions. Additionally, they showed a 2.2-fold increase (95% CI, 1.31-3.69; P < 0.01) in the incidence of end-stage renal disease (ESRD). CONCLUSIONS:Patients with sleep apnea are at increased risk for chronic kidney disease and end-stage renal disease compared with the general population. As such, screening renal function and treatment of chronic kidney disease is an important issue in patients with sleep apnea.
Authors: Sofia Ramiro; Helga Radner; Désirée M van der Heijde; Rachelle Buchbinder; Daniel Aletaha; Robert B Landewé Journal: J Rheumatol Suppl Date: 2012-09
Authors: Kelsie M Full; Chandra L Jackson; Casey M Rebholz; Kunihiro Matsushita; Pamela L Lutsey Journal: J Am Soc Nephrol Date: 2020-06-26 Impact factor: 10.121
Authors: Carmine Zoccali; Raymond Vanholder; Ziad A Massy; Alberto Ortiz; Pantelis Sarafidis; Friedo W Dekker; Danilo Fliser; Denis Fouque; Gunnar H Heine; Kitty J Jager; Mehmet Kanbay; Francesca Mallamaci; Gianfranco Parati; Patrick Rossignol; Andrzej Wiecek; Gerard London Journal: Nat Rev Nephrol Date: 2017-04-24 Impact factor: 28.314
Authors: Miklos Z Molnar; Istvan Mucsi; Marta Novak; Zoltan Szabo; Amado X Freire; Kim M Huch; Onyebuchi A Arah; Jennie Z Ma; Jun L Lu; John J Sim; Elani Streja; Kamyar Kalantar-Zadeh; Csaba P Kovesdy Journal: Thorax Date: 2015-06-02 Impact factor: 9.139