Literature DB >> 25408884

A mitochondrial strategy for safeguarding the reprogrammed genome.

Alessandro Prigione1, James Adjaye2.   

Abstract

Genomic aberrations induced by somatic cell reprogramming are a major drawback for future applications of this technology in regenerative medicine. A new study by Ji et al. published in Stem Cell Reports suggests a counteracting strategy based on balancing the mitochondrial/oxidative stress pathway through antioxidant supplementation.

Entities:  

Keywords:  Antioxidants; Genomic aberrations; Mitochondria; Reprogramming; iPSCs

Year:  2014        PMID： 25408884      PMCID： PMC4230514          DOI： 10.1186/2045-9769-3-5

Source DB:  PubMed          Journal:  Cell Regen (Lond)        ISSN： 2045-9769


  21 in total

Review 1.  Oxidants, oxidative stress and the biology of ageing.

Authors:  T Finkel; N J Holbrook
Journal:  Nature       Date:  2000-11-09       Impact factor: 49.962

2.  Hypoxia enhances the generation of induced pluripotent stem cells.

Authors:  Yoshinori Yoshida; Kazutoshi Takahashi; Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka
Journal:  Cell Stem Cell       Date:  2009-08-27       Impact factor: 24.633

3.  Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.

Authors:  Alessandro Prigione; Björn Lichtner; Heiner Kuhl; Eduard A Struys; Mirjam Wamelink; Hans Lehrach; Markus Ralser; Bernd Timmermann; James Adjaye
Journal:  Stem Cells       Date:  2011-09       Impact factor: 6.277

4.  Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression.

Authors:  Linzhao Cheng; Nancy F Hansen; Ling Zhao; Yutao Du; Chunlin Zou; Frank X Donovan; Bin-Kuan Chou; Guangyu Zhou; Shijie Li; Sarah N Dowey; Zhaohui Ye; Settara C Chandrasekharappa; Huanming Yang; James C Mullikin; P Paul Liu
Journal:  Cell Stem Cell       Date:  2012-03-02       Impact factor: 24.633

5.  Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

Authors:  Clifford D L Folmes; Timothy J Nelson; Almudena Martinez-Fernandez; D Kent Arrell; Jelena Zlatkovic Lindor; Petras P Dzeja; Yasuhiro Ikeda; Carmen Perez-Terzic; Andre Terzic
Journal:  Cell Metab       Date:  2011-08-03       Impact factor: 27.287

6.  Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.

Authors:  Margaret A Young; David E Larson; Chiao-Wang Sun; Daniel R George; Li Ding; Christopher A Miller; Ling Lin; Kevin M Pawlik; Ken Chen; Xian Fan; Heather Schmidt; Joelle Kalicki-Veizer; Lisa L Cook; Gary W Swift; Ryan T Demeter; Michael C Wendl; Mark S Sands; Elaine R Mardis; Richard K Wilson; Tim M Townes; Timothy J Ley
Journal:  Cell Stem Cell       Date:  2012-04-26       Impact factor: 24.633

7.  Metabolic oxidation regulates embryonic stem cell differentiation.

Authors:  Oscar Yanes; Julie Clark; Diana M Wong; Gary J Patti; Antonio Sánchez-Ruiz; H Paul Benton; Sunia A Trauger; Caroline Desponts; Sheng Ding; Gary Siuzdak
Journal:  Nat Chem Biol       Date:  2010-05-02       Impact factor: 15.040

8.  HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

Authors:  Alessandro Prigione; Nadine Rohwer; Sheila Hoffmann; Barbara Mlody; Katharina Drews; Raul Bukowiecki; Katharina Blümlein; Erich E Wanker; Markus Ralser; Thorsten Cramer; James Adjaye
Journal:  Stem Cells       Date:  2014-02       Impact factor: 6.277

9.  Somatic coding mutations in human induced pluripotent stem cells.

Authors:  Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Journal:  Nature       Date:  2011-03-03       Impact factor: 49.962

10.  Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network.

Authors:  Nancy Mah; Ying Wang; Mei-Chih Liao; Alessandro Prigione; Justyna Jozefczuk; Björn Lichtner; Katharina Wolfrum; Manuela Haltmeier; Max Flöttmann; Martin Schaefer; Alexander Hahn; Ralf Mrowka; Edda Klipp; Miguel A Andrade-Navarro; James Adjaye
Journal:  PLoS One       Date:  2011-08-31       Impact factor: 3.240
View more
  2 in total

Review 1.  Metabolic restructuring and cell fate conversion.

Authors:  Alessandro Prigione; María Victoria Ruiz-Pérez; Raul Bukowiecki; James Adjaye
Journal:  Cell Mol Life Sci       Date:  2015-01-14       Impact factor: 9.261

2.  Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate.

Authors:  Alejandro Vazquez-Martin; Chris Van den Haute; Sílvia Cufí; Bruna Corominas-Faja; Elisabet Cuyàs; Eugeni Lopez-Bonet; Esther Rodriguez-Gallego; Salvador Fernández-Arroyo; Jorge Joven; Veerle Baekelandt; Javier A Menendez
Journal:  Aging (Albany NY)       Date:  2016-07       Impact factor: 5.682
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.