Literature DB >> 2540881

Evidence for the involvement of nigral GABAA receptors in seizures of adult rats.

E F Sperber1, J N Wurpel, D Y Zhao, S L Moshé.   

Abstract

Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABAA and GABAB), are preferentially involved in this GABAergic seizure suppression mechanism. Adult rats were intranigrally infused with muscimol (GABAA receptor agonist), bicuculline (GABAA receptor antagonist) or baclofen (GABAB receptor agonist) and were exposed to flurothyl seizures. Results indicated that while infusions of muscimol had an anticonvulsant effect, infusions of bicuculline had a proconvulsant effect. Baclofen infusions were found to have no effect on seizures. These findings suggest an involvement of the nigral GABAA receptors in the mediation of seizures in adult rats.

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Year:  1989        PMID： 2540881     DOI： 10.1016/0006-8993(89)90211-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  The expression of GABA(A) receptor subunits in the substantia nigra is developmentally regulated and region-specific.

Authors:  J Velísková; H Kubová; L K Friedman; R Wu; E F Sperber; R S Zukin; S L Moshé
Journal:  Ital J Neurol Sci       Date:  1998-08

Review 2.  Organization and physiology of the substantia nigra.

Authors:  H Condé
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

Review 3.  Sex dimorphism in seizure-controlling networks.

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Journal:  Neurobiol Dis       Date:  2014-05-20       Impact factor: 5.996

4.  Metabolic environment in substantia nigra reticulata is critical for the expression and control of hypoglycemia-induced seizures.

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Review 5.  Animal models of absence epilepsies: what do they model and do sex and sex hormones matter?

Authors:  Gilles van Luijtelaar; Filiz Yilmaz Onat; Martin J Gallagher
Journal:  Neurobiol Dis       Date:  2014-08-15       Impact factor: 5.996

6.  Update on the role of substantia nigra pars reticulata in the regulation of seizures.

Authors:  Jana Velísková; Solomon L Moshé
Journal:  Epilepsy Curr       Date:  2006 May-Jun       Impact factor: 7.500

7.  Antipyretic and antinociceptive effects of Nauclea latifolia root decoction and possible mechanisms of action.

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Journal:  Pharm Biol       Date:  2010-09-07       Impact factor: 3.503

8.  Baclofen prevents rapid amygdala kindling in adult rats.

Authors:  J N Wurpel
Journal:  Experientia       Date:  1994-05-15

Review 9.  Sexually dimorphic expression of KCC2 and GABA function.

Authors:  Aristea S Galanopoulou
Journal:  Epilepsy Res       Date:  2008-06-03       Impact factor: 3.045

Review 10.  The epileptic hypothesis: developmentally related arguments based on animal models.

Authors:  Aristea S Galanopoulou; Solomon L Moshé
Journal:  Epilepsia       Date:  2009-08       Impact factor: 5.864
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