| Literature DB >> 2540845 |
C P Klein1, P Patka, W den Hollander.
Abstract
This study examines the biodegradation behaviour of calcium phosphate macroporous bioceramics consisting of hydroxylapatite or beta-whitlockite implants. The implantations were performed in hard tissue of femora and muscular tissue of dogs for periods of 6 and 12 month. With microradiography and light microscopy, respectively, of ground and thin sections it was shown that hydroxylapatite remained unchanged and beta-whitlockite degraded within 6 month in bone tissue. In the muscular tissue, the biodegradation of beta-whitlockite was slower. In addition, beta-whitlockite gave rise to a cellular response of lymphocytes and plasma cells rather than hydroxylapatite in the soft tissue region. For tissue response hydroxylapatite is more suitable as an implant material than beta-whitlockite.Entities:
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Year: 1989 PMID： 2540845 DOI： 10.1016/0142-9612(89)90011-2
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479