Sung Wook Park1, Jeong-Min Hwang. 1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
PURPOSE: The aim of the study was to evaluate the relationship between visual function and retinal nerve fiber layer thickness (RNFLT) determined using Stratus optical coherence tomography (OCT) in patients with autosomal dominant optic atrophy (ADOA). METHODS: The study was a retrospective, institutional, and comparative case series. Thirty-six consecutive patients with ADOA and 72 age-matched normal controls were compared with regard to RNFLT, best-corrected visual acuity (BCVA), and visual field. RESULTS: The relative reduction of RNFLT of ADOA patients was most evident in the temporal quadrant (56.8%), followed by the inferior (35.5%), superior (27.2%), and nasal quadrants (26.4%). In ADOA patients, BCVA decreased with RNFL thinning (p < 0.001), and was not related to age (p = 0.210). Papillomacular bundle RNFLT decreased with age throughout the study period of 3.7 ± 2.3 years (-3.83 ± 9.96 μm, p = 0.017). The presence of a superotemporal central scotoma (61.1%) was related to decreased inferotemporal RNFLT (7 and 8 o'clock, p = 0.016 and p = 0.036, respectively). CONCLUSIONS: The papillomacular bundle RNFL of ADOA is most vulnerable and progressively damaged with age, despite early temporal RNFL loss. Early loss of inferior temporal RNFL in ADOA is related to superotemporal central scotoma.
PURPOSE: The aim of the study was to evaluate the relationship between visual function and retinal nerve fiber layer thickness (RNFLT) determined using Stratus optical coherence tomography (OCT) in patients with autosomal dominant optic atrophy (ADOA). METHODS: The study was a retrospective, institutional, and comparative case series. Thirty-six consecutive patients with ADOA and 72 age-matched normal controls were compared with regard to RNFLT, best-corrected visual acuity (BCVA), and visual field. RESULTS: The relative reduction of RNFLT of ADOA patients was most evident in the temporal quadrant (56.8%), followed by the inferior (35.5%), superior (27.2%), and nasal quadrants (26.4%). In ADOA patients, BCVA decreased with RNFL thinning (p < 0.001), and was not related to age (p = 0.210). Papillomacular bundle RNFLT decreased with age throughout the study period of 3.7 ± 2.3 years (-3.83 ± 9.96 μm, p = 0.017). The presence of a superotemporal central scotoma (61.1%) was related to decreased inferotemporal RNFLT (7 and 8 o'clock, p = 0.016 and p = 0.036, respectively). CONCLUSIONS: The papillomacular bundle RNFL of ADOA is most vulnerable and progressively damaged with age, despite early temporal RNFL loss. Early loss of inferior temporal RNFL in ADOA is related to superotemporal central scotoma.
Authors: Massimo Cesareo; Elena Ciuffoletti; Alessio Martucci; Jacopo Sebastiani; Roberto Pietro Sorge; Eleonora Lamantea; Barbara Garavaglia; Federico Ricci; Andrea Cusumano; Carlo Nucci; Francesco Brancati Journal: PLoS One Date: 2017-03-30 Impact factor: 3.240