Juho Tynkkynen1, Tiina Laatikainen2, Veikko Salomaa3, Aki S Havulinna3, Stefan Blankenberg4, Tanja Zeller4, Jussi A Hernesniemi1. 1. North Karelia Central Hospital, Joensuu, Finland. 2. National Institute for Health and Welfare, Helsinki, Finland Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland Hospital District of North Karelia, Joensuu, Finland. 3. National Institute for Health and Welfare, Helsinki, Finland. 4. German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel University Heart Center Hamburg, Department of General and Interventional Cardiology, Germany.
Abstract
BACKGROUND: Memory disorders and Alzheimer's disease (AD) share the same risk factors with cardiovascular diseases. OBJECTIVE: We tested whether elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels would predict any incident dementia or AD. METHODS: The association between NT-proBNP and the risk of dementia was evaluated in a total of 7,158 subjects without previous memory disorders in a prospective study with a median follow-up of 13.8 years. RESULTS: A total of 220 new dementia cases occurred, of which 149 were AD. Baseline logNT-proBNP levels were associated significantly with the risk of dementia in the entire study population (HR 1.32, 95%CI 1.17-1.56, p = 0.001) per 1SD difference, adjusted for multiple cardiovascular risk factors. Integrated discrimination improvement (IDI) and continuous net-reclassification improvement (continuous NRI) were improved in the study population over 40 years of age: continuous NRI was 17.5% (95%CI 4.4-30.6%, p = 0.009) and IDI was 0.005 (95%CI 0.001-0.010, p = 0.021). Regarding AD, the HR for 1SD logNT-proBNP change was 1.23 (95%CI 1.01-1.49, p = 0.040) in the entire study population, but no IDI or continuous NRI improvement was seen. CONCLUSION: NT-proBNP is also an independent risk marker for dementia, and patient discrimination regarding dementia risk could be improved by using it.
BACKGROUND:Memory disorders and Alzheimer's disease (AD) share the same risk factors with cardiovascular diseases. OBJECTIVE: We tested whether elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels would predict any incident dementia or AD. METHODS: The association between NT-proBNP and the risk of dementia was evaluated in a total of 7,158 subjects without previous memory disorders in a prospective study with a median follow-up of 13.8 years. RESULTS: A total of 220 new dementia cases occurred, of which 149 were AD. Baseline logNT-proBNP levels were associated significantly with the risk of dementia in the entire study population (HR 1.32, 95%CI 1.17-1.56, p = 0.001) per 1SD difference, adjusted for multiple cardiovascular risk factors. Integrated discrimination improvement (IDI) and continuous net-reclassification improvement (continuous NRI) were improved in the study population over 40 years of age: continuous NRI was 17.5% (95%CI 4.4-30.6%, p = 0.009) and IDI was 0.005 (95%CI 0.001-0.010, p = 0.021). Regarding AD, the HR for 1SD logNT-proBNP change was 1.23 (95%CI 1.01-1.49, p = 0.040) in the entire study population, but no IDI or continuous NRI improvement was seen. CONCLUSION: NT-proBNP is also an independent risk marker for dementia, and patient discrimination regarding dementia risk could be improved by using it.
Authors: Yashashwi Pokharel; Farah Mouhanna; Andrea L C Schneider; Andreea M Rawlings; David S Knopman; Vijay Nambi; Salim S Virani; Ron C Hoogeveen; Alvaro Alonso; Gerardo Heiss; Josef Coresh; Thomas Mosley; Rebecca Gottesman; Elizabeth Selvin; Christie Ballantyne; Melinda C Power Journal: J Am Geriatr Soc Date: 2019-07-30 Impact factor: 5.562
Authors: Juho Tynkkynen; Jussi A Hernesniemi; Tiina Laatikainen; Aki S Havulinna; Perttu Salo; Stefan Blankenberg; Tanja Zeller; Veikko Salomaa Journal: J Neurol Date: 2016-12-30 Impact factor: 4.849
Authors: Juho Tynkkynen; Jussi A Hernesniemi; Tiina Laatikainen; Aki S Havulinna; Jouko Sundvall; Jaana Leiviskä; Perttu Salo; Veikko Salomaa Journal: Age (Dordr) Date: 2016-09-23
Authors: Mohammad R Ostovaneh; Kasra Moazzami; Kihei Yoneyama; Bharath A Venkatesh; Susan R Heckbert; Colin O Wu; Steven Shea; Wendy S Post; Annette L Fitzpatrick; Gregory L Burke; Hossein Bahrami; Otto A Sanchez; Lori B Daniels; Erin D Michos; David A Bluemke; João A C Lima Journal: Hypertension Date: 2019-12-23 Impact factor: 10.190