Literature DB >> 25407638

Out of the active site binding pocket for carbonic anhydrase inhibitors.

Katia D'Ambrosio1, Simone Carradori, Simona M Monti, Martina Buonanno, Daniela Secci, Daniela Vullo, Claudiu T Supuran, Giuseppina De Simone.   

Abstract

A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site.

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Year:  2015        PMID： 25407638     DOI： 10.1039/c4cc07320g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

1.  Prosystemin, a prohormone that modulates plant defense barriers, is an intrinsically disordered protein.

Authors:  Martina Buonanno; Mariangela Coppola; Ilaria Di Lelio; Donata Molisso; Marilisa Leone; Francesco Pennacchio; Emma Langella; Rosa Rao; Simona Maria Monti
Journal:  Protein Sci       Date:  2017-12-05       Impact factor: 6.725

2.  Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer.

Authors:  Wagdy M Eldehna; Alessio Nocentini; Zainab M Elsayed; Tarfah Al-Warhi; Nada Aljaeed; Ohoud J Alotaibi; Mohammad M Al-Sanea; Hatem A Abdel-Aziz; Claudiu T Supuran
Journal:  ACS Med Chem Lett       Date:  2020-03-18       Impact factor: 4.345

3.  α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors.

Authors:  Alessio Nocentini; Alessia Lucidi; Francesca Perut; Annamaria Massa; Daniela Tomaselli; Paola Gratteri; Nicola Baldini; Dante Rotili; Antonello Mai; Claudiu T Supuran
Journal:  ACS Med Chem Lett       Date:  2019-02-19       Impact factor: 4.345

4.  Carbonic anhydrase II in complex with carboxylic acid-based inhibitors.

Authors:  Carrie L Lomelino; Robert McKenna
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2019-02-20       Impact factor: 1.056

Review 5.  Non-Classical Inhibition of Carbonic Anhydrase.

Authors:  Carrie L Lomelino; Claudiu T Supuran; Robert McKenna
Journal:  Int J Mol Sci       Date:  2016-07-16       Impact factor: 5.923

6.  An update on anticancer drug development and delivery targeting carbonic anhydrase IX.

Authors:  Justina Kazokaitė; Ashok Aspatwar; Seppo Parkkila; Daumantas Matulis
Journal:  PeerJ       Date:  2017-11-23       Impact factor: 2.984

7.  Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.

Authors:  Ylenia Cau; Daniela Vullo; Mattia Mori; Elena Dreassi; Claudiu T Supuran; Maurizio Botta
Journal:  Molecules       Date:  2017-12-22       Impact factor: 4.411

Review 8.  Nitric oxide donors and selective carbonic anhydrase inhibitors: a dual pharmacological approach for the treatment of glaucoma, cancer and osteoporosis.

Authors:  Simone Carradori; Adriano Mollica; Celeste De Monte; Arianna Ganese; Claudiu T Supuran
Journal:  Molecules       Date:  2015-03-31       Impact factor: 4.411

9.  Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives.

Authors:  Hatem A Abuelizz; Rabab El Dib; Mohamed Marzouk; El-Hassane Anouar; Yousreya A Maklad; Hanan N Attia; Rashad Al-Salahi
Journal:  Molecules       Date:  2017-06-30       Impact factor: 4.411

10.  Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors.

Authors:  P V Sri Ramya; Srinivas Angapelly; Andrea Angeli; Chander Singh Digwal; Mohammed Arifuddin; Bathini Nagendra Babu; Claudiu T Supuran; Ahmed Kamal
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051
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