| Literature DB >> 2540643 |
J A Raaijmakers1, C Beneker, E C van Geffen, T M Meisters, P Pover.
Abstract
In this study the, in vitro, influence of arachidonic acid metabolites on human beta-adrenoceptors was investigated. Incubation of normal human pulmonary membranes with PAF, LTB4 and LTC4 affected pulmonary beta-adrenoceptor properties, as was shown in radioligand binding studies. The same mediators were able to induce a decreased lymphocyte cAMP synthesis. It is concluded that beta-adrenoceptor deficiencies, that can be demonstrated in peripheral lung tissue of COLD patients, may result from pathological processes such as inflammation.Entities:
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Year: 1989 PMID： 2540643 DOI： 10.1007/bf02126558
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299