Literature DB >> 25406006

Cone snail venomics: from novel biology to novel therapeutics.

Jutty Rajan Prashanth1, Andreas Brust, Ai-Hua Jin, Paul F Alewood, Sébastien Dutertre, Richard J Lewis.   

Abstract

Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided discovery methods have been replaced by high-throughput bioassays integrated with advanced MS and next-generation sequencing, ushering in the era of 'venomics'. In this review, we focus on the impact of venomics on the understanding of cone snail biology as well as the application of venomics to accelerate the discovery of new conotoxins. We also discuss the continued importance of medicinal chemistry approaches to optimize conotoxins for clinical use, with a descriptive case study of MrIA featured.

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Year:  2014        PMID： 25406006     DOI： 10.4155/fmc.14.99

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  24 in total

Review 1.  Sodium channels and pain: from toxins to therapies.

Authors:  Fernanda C Cardoso; Richard J Lewis
Journal:  Br J Pharmacol       Date:  2017-09-02       Impact factor: 8.739

2.  Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia).

Authors:  Qiwen Liao; Guiyi Gong; Terence C W Poon; Irene L Ang; Kate M K Lei; Shirley Weng In Siu; Clarence Tsun Ting Wong; Gandhi Rádis-Baptista; Simon Ming-Yuen Lee
Journal:  Arch Toxicol       Date:  2019-06-15       Impact factor: 5.153

Review 3.  Nature-Derived Peptides: A Growing Niche for GPCR Ligand Discovery.

Authors:  Edin Muratspahić; Michael Freissmuth; Christian W Gruber
Journal:  Trends Pharmacol Sci       Date:  2019-04-05       Impact factor: 14.819

Review 4.  Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins.

Authors:  Denis Kudryavtsev; Irina Shelukhina; Catherine Vulfius; Tatyana Makarieva; Valentin Stonik; Maxim Zhmak; Igor Ivanov; Igor Kasheverov; Yuri Utkin; Victor Tsetlin
Journal:  Toxins (Basel)       Date:  2015-05-14       Impact factor: 4.546

5.  Review: Cav2.3 R-type Voltage-Gated Ca2+ Channels - Functional Implications in Convulsive and Non-convulsive Seizure Activity.

Authors:  Carola Wormuth; Andreas Lundt; Christina Henseler; Ralf Müller; Karl Broich; Anna Papazoglou; Marco Weiergräber
Journal:  Open Neurol J       Date:  2016-09-30

6.  Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail.

Authors:  Bingmiao Gao; Chao Peng; Bo Lin; Qin Chen; Junqing Zhang; Qiong Shi
Journal:  Toxins (Basel)       Date:  2017-07-06       Impact factor: 4.546

7.  A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails.

Authors:  Alexander Fedosov; Paul Zaharias; Nicolas Puillandre
Journal:  Proc Biol Sci       Date:  2021-07-07       Impact factor: 5.530

8.  In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii.

Authors:  Marco A De León-Nava; Eunice Romero-Núñez; Angélica Luna-Nophal; Johanna Bernáldez-Sarabia; Liliana N Sánchez-Campos; Alexei F Licea-Navarro; Jorge Morales-Montor; Saé Muñiz-Hernández
Journal:  Mar Drugs       Date:  2016-04-08       Impact factor: 5.118

9.  A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity.

Authors:  Zhuguo Liu; Peter Bartels; Mahsa Sadeghi; Tianpeng Du; Qing Dai; Cui Zhu; Shuo Yu; Shuo Wang; Mingxin Dong; Ting Sun; Jiabin Guo; Shuangqing Peng; Ling Jiang; David J Adams; Qiuyun Dai
Journal:  Sci Rep       Date:  2018-01-17       Impact factor: 4.379

Review 10.  Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery.

Authors:  Bingmiao Gao; Chao Peng; Jiaan Yang; Yunhai Yi; Junqing Zhang; Qiong Shi
Journal:  Toxins (Basel)       Date:  2017-12-07       Impact factor: 4.546
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