Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Taming hazardous chemistry in flow: the continuous processing of diazo and diazonium compounds.

Literature DB >> 25404044

Taming hazardous chemistry in flow: the continuous processing of diazo and diazonium compounds.

Benjamin J Deadman¹, Stuart G Collins, Anita R Maguire.

Abstract

The synthetic utilities of the diazo and diazonium groups are matched only by their reputation for explosive decomposition. Continuous processing technology offers new opportunities to make and use these versatile intermediates at a range of scales with improved safety over traditional batch processes. In this minireview, the state of the art in the continuous flow processing of reactive diazo and diazonium species is discussed.

Entities: Chemical

Keywords: continuous processing; diazocarbonyls; diazomethane; diazonium ions; flow chemistry

Mesh：

Substances：

Year: 2014 PMID： 25404044 DOI： 10.1002/chem.201404348

Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236

Keyword Cloud
Cited

11 in total

Review 1. Continuous Flow Technology as an Enabler for Innovative Transformations Exploiting Carbenes, Nitrenes, and Benzynes.

Authors: Kian Donnelly; Marcus Baumann
Journal: J Org Chem Date: 2022-06-14 Impact factor: 4.198

2. Lab-scale production of anhydrous diazomethane using membrane separation technology.

Authors: Doris Dallinger; C Oliver Kappe
Journal: Nat Protoc Date: 2017-09-14 Impact factor: 13.491

3. A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.

Authors: Jian-Siang Poh; Duc N Tran; Claudio Battilocchio; Joel M Hawkins; Steven V Ley
Journal: Angew Chem Int Ed Engl Date: 2015-05-26 Impact factor: 15.336

4. Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation.

Authors: Olga C Dennehy; Valérie M Y Cacheux; Benjamin J Deadman; Denis Lynch; Stuart G Collins; Humphrey A Moynihan; Anita R Maguire
Journal: Beilstein J Org Chem Date: 2016-11-24 Impact factor: 2.883

5. Unsymmetrical difunctionalization of cyclooctadiene under continuous flow conditions: expanding the scope of ring opening metathesis polymerization.

Authors: Xianwang Shen; Honghong Gong; Yang Zhou; Yucheng Zhao; Jun Lin; Mao Chen
Journal: Chem Sci Date: 2018-01-08 Impact factor: 9.825

Taming hazardous chemistry in flow: the continuous processing of diazo and diazonium compounds.

Review 1. Continuous Flow Technology as an Enabler for Innovative Transformations Exploiting Carbenes, Nitrenes, and Benzynes.

2. Lab-scale production of anhydrous diazomethane using membrane separation technology.

3. A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.

4. Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation.

5. Unsymmetrical difunctionalization of cyclooctadiene under continuous flow conditions: expanding the scope of ring opening metathesis polymerization.

6. A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions.

Review 7. Assessing the possibilities of designing a unified multistep continuous flow synthesis platform.

8. Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides.

9. Exploring Flow Procedures for Diazonium Formation.

10. The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow.