Carolien Konijnenberg1, Annika Melinder. 1. The Cognitive Developmental Research Unit, Department of Psychology, University of Oslo, Oslo, Norway.
Abstract
AIMS: To examine whether prenatal exposure to opioid agonist medication is associated with visual selective attention and general attention problems in early childhood. METHOD: Twenty-two children (mean age = 52.17 months, SD = 1.81) prenatally exposed to methadone, 9 children (mean age = 52.41 months, SD = 1.42) prenatally exposed to buprenorphine and 25 nonexposed comparison children (mean age = 51.44 months, SD = 1.31) were tested. Visual selective attention was measured with a Tobii 1750 Eye Tracker using a spatial negative priming paradigm. Attention problems were measured using the Child Behavior Checklist. RESULTS: The comparison group demonstrated a larger spatial negative priming effect (mean = 23.50, SD = 45.50) than the exposed group [mean = -6.84, SD = 86.39, F(1,50) = 5.91, p = 0.019, η(2) = 0.11]. No difference in reported attention problems was found [F(1,51) = 1.63, p = 0.21, η(2) = 0.03]. Neonatal abstinence syndrome and prenatal exposure to marijuana were found to predict slower saccade latencies in the exposed group (b = 54.55, SE = 23.56, p = 0.03 and b = 88.86, SE = 32.07, p = 0.01, respectively). CONCLUSION: Although exposed children did not appear to have attention deficits in daily life, lower performance on the SNP task indicates subtle alteration in the attention system.
AIMS: To examine whether prenatal exposure to opioid agonist medication is associated with visual selective attention and general attention problems in early childhood. METHOD: Twenty-two children (mean age = 52.17 months, SD = 1.81) prenatally exposed to methadone, 9 children (mean age = 52.41 months, SD = 1.42) prenatally exposed to buprenorphine and 25 nonexposed comparison children (mean age = 51.44 months, SD = 1.31) were tested. Visual selective attention was measured with a Tobii 1750 Eye Tracker using a spatial negative priming paradigm. Attention problems were measured using the Child Behavior Checklist. RESULTS: The comparison group demonstrated a larger spatial negative priming effect (mean = 23.50, SD = 45.50) than the exposed group [mean = -6.84, SD = 86.39, F(1,50) = 5.91, p = 0.019, η(2) = 0.11]. No difference in reported attention problems was found [F(1,51) = 1.63, p = 0.21, η(2) = 0.03]. Neonatal abstinence syndrome and prenatal exposure to marijuana were found to predict slower saccade latencies in the exposed group (b = 54.55, SE = 23.56, p = 0.03 and b = 88.86, SE = 32.07, p = 0.01, respectively). CONCLUSION: Although exposed children did not appear to have attention deficits in daily life, lower performance on the SNP task indicates subtle alteration in the attention system.
Authors: Elisabeth Conradt; Tess Flannery; Judy L Aschner; Robert D Annett; Lisa A Croen; Cristiane S Duarte; Alexander M Friedman; Constance Guille; Monique M Hedderson; Julie A Hofheimer; Miranda R Jones; Christine Ladd-Acosta; Monica McGrath; Angela Moreland; Jenae M Neiderhiser; Ruby H N Nguyen; Jonathan Posner; Judith L Ross; David A Savitz; Steven J Ondersma; Barry M Lester Journal: Pediatrics Date: 2019-09 Impact factor: 9.703
Authors: Victoria J Monnelly; Devasuda Anblagan; Alan Quigley; Manuel Blesa Cabez; E Sarah Cooper; Helen Mactier; Scott I Semple; Mark E Bastin; James P Boardman Journal: Neuroimage Clin Date: 2017-12-24 Impact factor: 4.881
Authors: Stacey L Klaman; Krystyna Isaacs; Anne Leopold; Joseph Perpich; Susan Hayashi; Jeff Vender; Melinda Campopiano; Hendrée E Jones Journal: J Addict Med Date: 2017 May/Jun Impact factor: 3.702
Authors: Victoria J Monnelly; Ruth Hamilton; Francesca M Chappell; Helen Mactier; James P Boardman Journal: Dev Med Child Neurol Date: 2018-12-03 Impact factor: 5.449
Authors: Barbara K Zedler; Ashley L Mann; Mimi M Kim; Halle R Amick; Andrew R Joyce; E Lenn Murrelle; Hendrée E Jones Journal: Addiction Date: 2016-06-30 Impact factor: 6.526