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Literature DB >> 25400988

Biomarkers of Barrett's esophagus.

Yasser Mahrous Fouad¹, Ibrahim Mostafa¹, Reem Yehia¹, Hisham El-Khayat¹.

Abstract

Barrett's esophagus is the strongest risk for esophageal adenocarcinoma (EAC). Metaplasia in patients with BE may progress to dysplasia and then invasive carcinoma. Well-defined diagnostic, progressive, predictive, and prognostic biomarkers are needed to identify the presence of the disease, estimate the risk of malignant transformation, and predict the therapeutic outcome and survival of EAC patients. There are many predictive and prognostic markers that lack substantial validation, and do not allow stratification of patients with gastroesophageal reflux disease in clinical practice for outcome and effectiveness of therapy. In this short review we summarize the current knowledge regarding possible biomarkers, focusing on the pathophysiologic mechanisms to improve prognostic and therapeutic approaches.

Entities: Disease Species

Keywords: Barrett’s esophagus; Biomarkers; Esophageal adenocarcinoma

Year: 2014 PMID： 25400988 PMCID： PMC4231509 DOI： 10.4291/wjgp.v5.i4.450

Source DB: PubMed Journal: World J Gastrointest Pathophysiol ISSN： 2150-5330

77 in total

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Journal: Surg Oncol Clin N Am Date: 2002-04 Impact factor: 3.495

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Journal: Appl Immunohistochem Mol Morphol Date: 2008-10

7. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

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Journal: Science Date: 2008-04-03 Impact factor: 47.728

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Journal: Hum Pathol Date: 2008-07-07 Impact factor: 3.466

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Journal: Clin Cancer Res Date: 2007-01-15 Impact factor: 12.531

7 in total

Review 1. Current state of prognostication, therapy and prospective innovations for Barrett's-related esophageal adenocarcinoma: a literature review.

Authors: Sumeet K Mittal; Joe Abdo; Malika P Adrien; Binyam A Bayu; Jay R Kline; Molly M Sullivan; Devendra K Agrawal
Journal: J Gastrointest Oncol Date: 2021-08

2. Molecules involved in the development of Barrett's esophagus phenotype in chronic eosinophilic esophagitis.

Authors: Sathisha Upparahalli Venkateshaiah; Chandra Sekhar Yadavalli; Hemanth Kumar Kandikattu; Sandeep Kumar; Lokanatha Oruganti; Anil Mishra
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2022-04-19 Impact factor: 4.871

Review 3. Gastroesophageal reflux and congenital gastrointestinal malformations.

Authors: Lucia Marseglia; Sara Manti; Gabriella D'Angelo; Eloisa Gitto; Carmelo Salpietro; Antonio Centorrino; Gianfranco Scalfari; Giuseppe Santoro; Pietro Impellizzeri; Carmelo Romeo
Journal: World J Gastroenterol Date: 2015-07-28 Impact factor: 5.742

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Authors: Chidi Amadi; Piers Gatenby
Journal: World J Gastroenterol Date: 2017-07-28 Impact factor: 5.742

Review 5. Towards screening Barrett's oesophagus: current guidelines, imaging modalities and future developments.

Authors: Ishaan Maitra; Ravindra Sudhachandra Date; Francis Luke Martin
Journal: Clin J Gastroenterol Date: 2020-06-03

6. LYN, a Key Gene From Bioinformatics Analysis, Contributes to Development and Progression of Esophageal Adenocarcinoma.

Authors: Dabiao Liu
Journal: Med Sci Monit Basic Res Date: 2015-12-21

Review 7. Role of Mitochondrial Markers in Improved Detection and Risk-Stratification in Barrett's Esophagus Patients.

Authors: Udhayvir S Grewal; Mehraj S Randhawa; Aryan Mehta
Journal: Yale J Biol Med Date: 2019-09-20

7 in total