BACKGROUND: Several lines of evidence have reported that serum angiotensin-converting enzyme (CD143) levels are genetically regulated by insertion/deletion (ins/del) polymorphism in intron 16 of the CD143 gene. In addition, published data on the association of ins/del polymorphism and sepsis risk yielded contradictory conclusions. Therefore, we determined to perform a meta-analysis to validate the association of much debate. Methods and major findings: Relevant literature was identified through weekly searches in databases and references of systematic reviews and the single studies incorporated in this meta-analysis. We combined ORs and its 95% CIs for several genetic models to evaluate the risk of sepsis associated with ins/del polymorphism. A total of seven studies were considered eligible for this analysis. We found significantly increased risk of sepsis in relation to the homozygote ins/ins (OR: 1.32, 95% CI: 1.04-1.68, P: 0.4201, for ins/ins vs. del/del), heterozygote del/ins (OR: 1.33, 95% CI: 1.11-1.61, P: 0.7937, for del/ins vs. del/del) and the two genotypes combined (OR: 1.33, 95% CI: 1.11-1.59, P: 0.7018, for ins/ins + del/ins vs. del/del). Subgroup analysis by age group showed a significant association in pediatric sepsis, but not in adult sepsis. CONCLUSIONS: The statistical data suggest that the CD143 gene ins/del polymorphism may influence the risk of sepsis, especially pediatric sepsis.
BACKGROUND: Several lines of evidence have reported that serum angiotensin-converting enzyme (CD143) levels are genetically regulated by insertion/deletion (ins/del) polymorphism in intron 16 of the CD143 gene. In addition, published data on the association of ins/del polymorphism and sepsis risk yielded contradictory conclusions. Therefore, we determined to perform a meta-analysis to validate the association of much debate. Methods and major findings: Relevant literature was identified through weekly searches in databases and references of systematic reviews and the single studies incorporated in this meta-analysis. We combined ORs and its 95% CIs for several genetic models to evaluate the risk of sepsis associated with ins/del polymorphism. A total of seven studies were considered eligible for this analysis. We found significantly increased risk of sepsis in relation to the homozygote ins/ins (OR: 1.32, 95% CI: 1.04-1.68, P: 0.4201, for ins/ins vs. del/del), heterozygote del/ins (OR: 1.33, 95% CI: 1.11-1.61, P: 0.7937, for del/ins vs. del/del) and the two genotypes combined (OR: 1.33, 95% CI: 1.11-1.59, P: 0.7018, for ins/ins + del/ins vs. del/del). Subgroup analysis by age group showed a significant association in pediatric sepsis, but not in adult sepsis. CONCLUSIONS: The statistical data suggest that the CD143 gene ins/del polymorphism may influence the risk of sepsis, especially pediatric sepsis.
Authors: J Spiegler; A Gilhaus; I R Konig; E Kattner; M Vochem; H Kuster; J Moller; D Muller; A Kribs; H Segerer; C Wieg; W Nikischin; A von der Wense; C Gebauer; E Herting; W Gopel Journal: Neonatology Date: 2009-07-02 Impact factor: 4.035
Authors: James A Tumlin; Raghavan Murugan; Adam M Deane; Marlies Ostermann; Laurence W Busse; Kealy R Ham; Kianoush Kashani; Harold M Szerlip; John R Prowle; Azra Bihorac; Kevin W Finkel; Alexander Zarbock; Lui G Forni; Shannan J Lynch; Jeff Jensen; Stew Kroll; Lakhmir S Chawla; George F Tidmarsh; Rinaldo Bellomo Journal: Crit Care Med Date: 2018-06 Impact factor: 7.598