Literature DB >> 25399574

The role of ERK5 in endothelial cell function.

Gopika N Nithianandarajah-Jones1, Bettina Wilm2, Christopher E P Goldring1, Jürgen Müller3, Michael J Cross1.   

Abstract

Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.

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Year:  2014        PMID： 25399574     DOI： 10.1042/BST20140276

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  10 in total

1.  Shear stress modulates endothelial KLF2 through activation of P2X4.

Authors:  R Sathanoori; F Rosi; B J Gu; J S Wiley; C E Müller; B Olde; D Erlinge
Journal:  Purinergic Signal       Date:  2015-01-08       Impact factor: 3.765

2.  Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling.

Authors:  Hanqiang Deng; Elizabeth Min; Nicolas Baeyens; Brian G Coon; Rui Hu; Zhen W Zhuang; Minghao Chen; Billy Huang; Titilayo Afolabi; Georgia Zarkada; Angela Acheampong; Kathleen McEntee; Anne Eichmann; Fang Liu; Bing Su; Michael Simons; Martin A Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  2021-09-14       Impact factor: 11.205

3.  Analysis of miRNA expression profiling in human umbilical vein endothelial cells affected by heat stress.

Authors:  Jie Liu; Guoguo Zhu; Siya Xu; Shixin Liu; Qiping Lu; Zhongzhi Tang
Journal:  Int J Mol Med       Date:  2017-10-05       Impact factor: 4.101

4.  Extracellular Signal-Regulated Kinase 5 is Required for Low-Concentration H2O2-Induced Angiogenesis of Human Umbilical Vein Endothelial Cells.

Authors:  Shan Jiang; Dongxin Zhang; Hong Huang; Yonghong Lei; Yan Han; Weidong Han
Journal:  Biomed Res Int       Date:  2017-04-30       Impact factor: 3.411

Review 5.  Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer.

Authors:  Galia Maik-Rachline; Avital Hacohen-Lev-Ran; Rony Seger
Journal:  Int J Mol Sci       Date:  2019-03-08       Impact factor: 5.923

Review 6.  The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1.

Authors:  Jolien Fledderus; Byambasuren Vanchin; Marianne G Rots; Guido Krenning
Journal:  J Pers Med       Date:  2021-02-05

Review 7.  Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies.

Authors:  Li Li; Sainan Liu; Jianying Tan; Lai Wei; Dimeng Wu; Shuai Gao; Yajun Weng; Junying Chen
Journal:  J Tissue Eng       Date:  2022-03-24       Impact factor: 7.813

Review 8.  EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress.

Authors:  Roberta Giordo; Yusra M A Ahmed; Hilda Allam; Salah Abusnana; Lucia Pappalardo; Gheyath K Nasrallah; Arduino Aleksander Mangoni; Gianfranco Pintus
Journal:  Front Cell Dev Biol       Date:  2021-05-19

9.  Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells.

Authors:  Emma L Wilkinson; James E Sidaway; Michael J Cross
Journal:  J Cell Physiol       Date:  2017-08-03       Impact factor: 6.384

Review 10.  Remodeling of the Microvasculature: May the Blood Flow Be With You.

Authors:  Ricardo Santamaría; María González-Álvarez; Raquel Delgado; Sergio Esteban; Alicia G Arroyo
Journal:  Front Physiol       Date:  2020-10-15       Impact factor: 4.566
  10 in total

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