Literature DB >> 25397915

Tandem synthesis of 3-halo-5-substituted isoxazoles from 1-copper(I) alkynes and dihaloformaldoximes.

Wenwen Chen1, Bo Wang1, Nan Liu1, Dayun Huang1, Xinyan Wang1, Yuefei Hu1.   

Abstract

A tandem synthesis of 3-halo-5-substituted isoxazoles has been developed from 1-copper(I) alkynes and dihaloformaldoximes under base-free conditions. Thus, 1,3-dipolar cycloaddition and all its drawbacks can now be avoided completely.

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Year:  2014        PMID： 25397915     DOI： 10.1021/ol503008t

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  1 in total

1.  Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles.

Authors:  Bohdan A Chalyk; Andrii Khutorianskyi; Andrii Lysenko; Yulia Fil; Yuliya O Kuchkovska; Konstantin S Gavrilenko; Iulia Bakanovych; Yurii S Moroz; Alina O Gorlova; Oleksandr O Grygorenko
Journal:  J Org Chem       Date:  2019-11-08       Impact factor: 4.354
  1 in total

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