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Literature DB >> 2539596

Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence.

D A Relman¹, M Domenighini, E Tuomanen, R Rappuoli, S Falkow.

Abstract

Filamentous hemagglutinin is a surface-associated adherence protein of Bordetella pertussis, which is a component of some new acellular pertussis vaccines. The nucleotide sequence of an open reading frame that encompasses the filamentous hemagglutinin structural gene, fhaB, suggests that proteolytic processing is necessary to generate the mature 220-kDa filamentous hemagglutinin product. An Arg-Gly-Asp (RGD) tripeptide is found within filamentous hemagglutinin that may be involved in its adherence properties. An internal in-frame deletion in fhaB, encompassing the RGD region, causes loss of B. pertussis-binding to ciliated eukaryotic cells, confirming a potential role for this protein in host-cell binding and infection.

Entities: Chemical Disease Species

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Year: 1989 PMID： 2539596 PMCID： PMC286972 DOI： 10.1073/pnas.86.8.2637

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

37 in total

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Journal: J Virol Date: 1986-03 Impact factor: 5.103

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Journal: Infect Immun Date: 1985-05 Impact factor: 3.441

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Journal: Dev Biol Stand Date: 1985

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Authors: E Tuomanen; A Weiss
Journal: J Infect Dis Date: 1985-07 Impact factor: 5.226

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Authors: C Yanisch-Perron; J Vieira; J Messing
Journal: Gene Date: 1985 Impact factor: 3.688

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Journal: Infect Immun Date: 1984-11 Impact factor: 3.441

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Journal: Infect Immun Date: 1986-06 Impact factor: 3.441

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Journal: Mol Cell Biochem Date: 1986-04 Impact factor: 3.396

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Journal: J Exp Med Date: 1988-10-01 Impact factor: 14.307

145 in total

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Authors: L Bassinet; P Gueirard; B Maitre; B Housset; P Gounon; N Guiso
Journal: Infect Immun Date: 2000-04 Impact factor: 3.441

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Authors: B M van den Berg; H Beekhuizen; R J Willems; F R Mooi; R van Furth
Journal: Infect Immun Date: 1999-03 Impact factor: 3.441

3. The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies.

Authors: C E Belcher; J Drenkow; B Kehoe; T R Gingeras; N McNamara; H Lemjabbar; C Basbaum; D A Relman
Journal: Proc Natl Acad Sci U S A Date: 2000-12-05 Impact factor: 11.205

4. Stereotyped and specific gene expression programs in human innate immune responses to bacteria.

Authors: Jennifer C Boldrick; Ash A Alizadeh; Maximilian Diehn; Sandrine Dudoit; Chih Long Liu; Christopher E Belcher; David Botstein; Louis M Staudt; Patrick O Brown; David A Relman
Journal: Proc Natl Acad Sci U S A Date: 2002-01-22 Impact factor: 11.205

5. The Haemophilus influenzae Hia adhesin is an autotransporter protein that remains uncleaved at the C terminus and fully cell associated.

Authors: J W St Geme; D Cutter
Journal: J Bacteriol Date: 2000-11 Impact factor: 3.490

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Journal: Infect Immun Date: 1992-11 Impact factor: 3.441

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Authors: P A Cotter; J F Miller
Journal: Infect Immun Date: 1994-08 Impact factor: 3.441