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Literature DB >> 25395694

Synthesis and cell phototoxicity of a triply bridged fused diporphyrin appended with six thioglucose units.

Sunaina Singh^1,2, Amit Aggarwal^1,2, N V S Dinesh K Bhupathiraju¹, Brandon Newton³, Ahmad Nafees², Ruomei Gao^3,4, Charles Michael Drain^1,5.

Abstract

A triply bridged fused diporphyrin appended with six thioglucose units is reported. This new, chemically and photochemically stable amphiphilic compound is taken up by breast cancer cells and causes cell death upon light exposure. Photophysical studies reveal absorption bands in the near IR region, and photosensitized formation of singlet oxygen in high quantum yields.

Entities: CellLine Chemical Disease Gene Species

Keywords: Click Chemistry; Fluorescence; Photodynamic Therapy; Porphyrin; Thioglucose

Year: 2014 PMID： 25395694 PMCID： PMC4226442 DOI： 10.1016/j.tetlet.2014.09.085

Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.415

19 in total

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Journal: Chem Commun (Camb) Date: 2005-06-21 Impact factor: 6.222

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7. Synthesis and photophysics of an octathioglycosylated zinc(II) phthalocyanine.

Authors: Amit Aggarwal; Sunaina Singh; Yazhou Zhang; Mariah Anthes; Diana Samaroo; Ruomei Gao; Charles Michael Drain
Journal: Tetrahedron Lett Date: 2011-10-19 Impact factor: 2.415

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Journal: Bioorg Med Chem Lett Date: 2007-03-12 Impact factor: 2.823

9. Synthesis and photophysical properties of thioglycosylated chlorins, isobacteriochlorins, and bacteriochlorins for bioimaging and diagnostics.

Authors: Sunaina Singh; Amit Aggarwal; Sebastian Thompson; João P C Tomé; Xianchun Zhu; Diana Samaroo; Mikki Vinodu; Ruomei Gao; Charles Michael Drain
Journal: Bioconjug Chem Date: 2010-10-21 Impact factor: 4.774