Literature DB >> 25394971

[New surgical treatment options for bone tumors].

D Andreou1, M P Henrichs, G Gosheger, M Nottrott, A Streitbürger, J Hardes.   

Abstract

Primary bone neoplasms can be classified into benign, locally/aggressive and rarely metastasizing and malignant tumors. Patients with benign tumors usually undergo surgical treatment in cases of local symptoms, mainly consisting of pain or functional deficits due to compression of important anatomical structures, such as nerves or blood vessels. Locally/aggressive and rarely metastasizing tumors exhibit an infiltrative growth pattern, so that surgical treatment is necessary to prevent further destruction of bone leading to local instability. Finally, the surgical treatment of malignant tumors is, with few exceptions, considered to be a prerequisite for long-term survival, either alone or in combination with systemic chemotherapy. Whereas the main objective of surgery in the treatment of benign tumors is relief of local symptoms with a minimum amount of damage to healthy tissue and minimizing the risk of local recurrence while ensuring bone stability in locally aggressive and rarely metastasizing tumors, the primary goal in the operative treatment of bone sarcomas is the resection of the tumor with clear surgical margins followed by defect reconstruction and the preservation of function. This review examines the current developments in the surgical treatment of primary bone neoplasms with respect to the management of the tumors and novel reconstructive options.

Entities:  

Mesh:

Year:  2014        PMID: 25394971     DOI: 10.1007/s00292-014-2004-1

Source DB:  PubMed          Journal:  Pathologe        ISSN: 0172-8113            Impact factor:   1.011


  19 in total

1.  [Growing prostheses for reconstruction of lower limb defects in children].

Authors:  M Schinhan; P Funovics; M Dominkus; R Windhager
Journal:  Oper Orthop Traumatol       Date:  2012-07       Impact factor: 1.154

Review 2.  Expandable endoprostheses in malignant bone tumors in children: indications and limitations.

Authors:  Rainer Baumgart; Ulrich Lenze
Journal:  Recent Results Cancer Res       Date:  2009

Review 3.  Modular endoprosthetic reconstruction in malignant bone tumors: indications and limits.

Authors:  Maurice Balke; Helmut Ahrens; Arne Streitbürger; Georg Gosheger; Jendrik Hardes
Journal:  Recent Results Cancer Res       Date:  2009

4.  Silver-coated megaendoprostheses in a rabbit model--an analysis of the infection rate and toxicological side effects.

Authors:  Georg Gosheger; Jendrik Hardes; Helmut Ahrens; Arne Streitburger; Horst Buerger; Michael Erren; Andreas Gunsel; Fritz H Kemper; Winfried Winkelmann; Christof Von Eiff
Journal:  Biomaterials       Date:  2004-11       Impact factor: 12.479

5.  [Bone defect reconstruction in bone sarcoma surgery: tumour endoprosthesis versus biological reconstruction].

Authors:  A Streitbürger; G Gosheger; R Dieckmann; M Nottrott; H Ahrens; J Hardes
Journal:  Unfallchirurg       Date:  2014-07       Impact factor: 1.000

6.  Is sclerotherapy better than intralesional excision for treating aneurysmal bone cysts?

Authors:  Manish Kumar Varshney; Shishir Rastogi; Shah Alam Khan; Vivek Trikha
Journal:  Clin Orthop Relat Res       Date:  2009-10-23       Impact factor: 4.176

7.  Targeting receptor-activator of nuclear kappaB ligand in aneurysmal bone cysts: verification of target and therapeutic response.

Authors:  Dominic W Pelle; Jonathan W Ringler; Jacqueline D Peacock; Kevin Kampfschulte; Donald J Scholten; Mary M Davis; Deanna S Mitchell; Matthew R Steensma
Journal:  Transl Res       Date:  2014-03-21       Impact factor: 7.012

8.  Aneurysmal bone cysts: do simple treatments work?

Authors:  Krishna I A Reddy; F Sinnaeve; Czar Louie Gaston; Robert J Grimer; Simon R Carter
Journal:  Clin Orthop Relat Res       Date:  2014-02-15       Impact factor: 4.176

9.  Sclerotherapy with polidocanol for treatment of aneurysmal bone cysts.

Authors:  Otte Brosjö; Pierre Pechon; Asle Hesla; Panagiotis Tsagozis; Henrik Bauer
Journal:  Acta Orthop       Date:  2013-10-31       Impact factor: 3.717

10.  Response of an aggressive periosteal aneurysmal bone cyst (ABC) of the radius to denosumab therapy.

Authors:  Chantal Pauli; Bruno Fuchs; Christian Pfirrmann; Julia A Bridge; Silvia Hofer; Beata Bode
Journal:  World J Surg Oncol       Date:  2014-01-20       Impact factor: 2.754

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