| Literature DB >> 2539434 |
O I Aruoma1, S S Chaudhary, M Grootveld, B Halliwell.
Abstract
Iron(II) ions are able to form a weak complex (apparent equilibrium constant about 10(2) at pH 7.4 and 25 degrees C) with 2-deoxyribose over a range of pH values, including pH 7. Evidence for this complex formation has been obtained by spectrophotometric experiments and by studies of Fe(II) oxidation. Iron(II) ions bound to deoxyribose seem to react with H2O2, in a site-specific reaction, to form hydroxyl radicals (.OH) that immediately damage the deoxyribose molecule.Entities:
Mesh：
Substances：
Year: 1989 PMID： 2539434 DOI： 10.1016/0162-0134(89)80007-8
Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155